Department of Radiation Oncology
Position: Associate Professor
ORCID: 0000-0002-7920-7754
T +43 1 40400 26650
nicole.eder-nesvacil@meduniwien.ac.at
Keywords
Brachytherapy; Dose-Response Relationship, Radiation; Evidence-Based Medicine; Gynecology; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Quality Assurance, Health Care; Radiation Oncology; Ultrasound, High-Intensity Focused, Transrectal; Uncertainty
Research group(s)
- Medical Radiation Research
Head: Dietmar Georg
Research Area: The vision of our group is the optimization of the treatment outcome of radiation oncology, alone or in combination with established chemotherapy or novel targeted strategies of drug treatment, with conventional photon or innovative ion-beams.
Members: - Christian Doppler Laboratory for Image and knowledge dRivEN prEcision radiation oncology
Head: Barbara Knäusl
Research Area: Laboratory head: Barbara Knäusl and Maximilian Schmid
Members:
Research interests
My main research focus is to improve the state of the art of image-guided adaptive brachytherapy for gynaecological cancer, by development of modern software tools to facilitate access to clinical evidence for the relation of technical treatment parameters with clinical outcome. I am part of the international group which runs the EMBRACE studies for cervical cancer, as well as the GEC-ESTRO gyn network. Furthermore, I work on image-registration applications for therapy planning and therapy monitoring for brachytherapy.
In addition, I am part of a team who works on translating the state of the art method for 3D imaging for gynaecological brachytherapy - which is MRI - to settings with limited access to MRI. Ultrasound is a promising tool to image target volumes essential for brachytherapy treatment. In combination with CT for treatment planning. ultrasound has the potential to be widely used in high volume centers, and allow for precision brachytherapy to be applied for a vast number of patients.
Grants
- Evidence-based decision making for image-guided brachytherapy (2018)
Source of Funding: FWF (Austrian Science Fund), Programme Clinical Research
Principal Investigator
Selected publications
- Pötter, R. et al. (2021) ‘MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study’, The Lancet Oncology, 22(4), pp. 538–547. Available at: https://doi.org/10.1016/s1470-2045(20)30753-1.
- Schmid, M.P. et al. (2023) ‘Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image–Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study’, Journal of Clinical Oncology, 41(10), pp. 1933–1942. Available at: https://doi.org/10.1200/jco.22.01096.
- Westerveld, H. et al. (2020) ‘Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer’, The Lancet Oncology, 21(3), pp. e157–e167. Available at: https://doi.org/10.1016/s1470-2045(19)30855-1.
- Ecker, S. et al. (2023) ‘EviGUIDE - a tool for evidence-based decision making in image-guided adaptive brachytherapy for cervical cancer’, Radiotherapy and Oncology, 186, p. 109748. Available at: https://doi.org/10.1016/j.radonc.2023.109748.
- Ecker, S. et al. (2023) ‘Tools for large-scale data analytics of an international multi-center study in radiation oncology for cervical cancer’, Radiotherapy and Oncology, 182, p. 109524. Available at: https://doi.org/10.1016/j.radonc.2023.109524.