Heavy Ion Radiotherapy; Immunotherapy; Organoids; Pancreatic Cancer; Radiation Oncology; Radioimmunotherapy; Radiotherapy; Spheroids, Cellular
- Medical Radiation Research
Head: Dietmar Georg
Research Area: The vision of our group is the optimization of the treatment outcome of radiation oncology, alone or in combination with established chemotherapy or novel targeted strategies of drug treatment, with conventional photon or innovative ion-beams.
My main research focus is the biology of ion beam therapy and to understand how the physical advantages of ion beam therapy can be exploited for an improved therapy response in patients. A specific aim is the conversion of immunologically cold (irresponsive) tumors, such as pancreatic cancer, into immunologically hot (responsive) tumors. Immune-evasion is significantly linked to the tumor microenvironment. To adress this important key aspect, heterotypic 3D tumor models, consisting of tumor as well as stromal components, are used.
- Gruber, S. et al., 2018. Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis—Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation. International Journal of Molecular Sciences, 19(6), p.1684. Available at: http://dx.doi.org/10.3390/ijms19061684.
- Gruber, S. et al., 2018. Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa. Strahlentherapie und Onkologie, 194(8), pp.771–779. Available at: http://dx.doi.org/10.1007/s00066-018-1302-6.
- Gruber, S. et al., 2018. Protective effects of systemic dermatan sulfate treatment in a preclinical model of radiation-induced oral mucositis. Strahlentherapie und Onkologie, 194(7), pp.675–685. Available at: http://dx.doi.org/10.1007/s00066-018-1280-8.
- Gruber, S. et al., 2017. Early inflammatory changes in radiation-induced oral mucositis. Strahlentherapie und Onkologie, 193(6), pp.499–507. Available at: http://dx.doi.org/10.1007/s00066-017-1119-8.
- Gruber, S. et al., 2015. Local hypoxia in oral mucosa (mouse) during daily fractionated irradiation – Effect of pentoxifylline. Radiotherapy and Oncology, 116(3), pp.404–408. Available at: http://dx.doi.org/10.1016/j.radonc.2015.03.024.