Detail

Keywords

Animal models; Nephrology; Peritoneal Dialysis; Proteomics; Randomized Controlled Trial

Research group(s)

• Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis (CDL-MSRPD)
  Members:
  Klaus Kratochwill
  Rebecca Herzog

Techniques, methods & infrastructure

In our CDL we use omics techniques (transcriptomics, proteomics, metabolomics) to characterize molecular profiles of clinical samples and samples obtained from in-vitro and in-vivo models, using previously established bioinformatic tools as well as novel analytical approaches (high abundance protein depletion/low abundance protein enrichment approach, etc.)

Grants

• InfraPET (2023)
  Source of Funding: Vienna Business Agency, Innovation
  Principal Investigator
• PD3 - Proteome Analysis of Peritoneal Dialysis Cell Populations (2021)
  Source of Funding: FWF (Austrian Science Fund), Elise-Richter / Senior-Postdoc-Programm
  Principal Investigator
• Identification and Management of Patients at Risk – Outcome and Vascular Events in Peritoneal Dialysis (IMPROVE-PD) (2018)
  Source of Funding: EU, Horizon 2020 Marie Curie ITN
  Principal Investigator

Selected publications

1. Herzog, R. et al., 2021. Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin. Science Translational Medicine, 13(608). Available at: http://dx.doi.org/10.1126/scitranslmed.aaz9705.
2. Bartosova, M. et al., 2021. Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis. Circulation Research, 129(5). Available at: http://dx.doi.org/10.1161/CIRCRESAHA.121.319310.
3. Vychytil, A. et al., 2018. A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health. Kidney International, 94(6), pp.1227–1237. Available at: http://dx.doi.org/10.1016/j.kint.2018.08.031.
4. Herzog, R. et al., 2018. Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures. Molecular & Cellular Proteomics, 17(3), pp.516–532. Available at: http://dx.doi.org/10.1074/mcp.RA117.000186.
5. Herzog, R. et al., 2014. DynamicO-LinkedN-Acetylglucosamine Modification of Proteins Affects Stress Responses and Survival of Mesothelial Cells Exposed to Peritoneal Dialysis Fluids. Journal of the American Society of Nephrology, 25(12), pp.2778–2788. Available at: http://dx.doi.org/10.1681/ASN.2013101128.