Acute Coronary Syndrome; Neutrophil Activation; Pulmonary Artery
My main focus is to understand the importance of the innate immune system in cardiovascular disease. Specifically, our group emphasizes the role of Neutrophil Extracellular Traps (NETs), an effector mechanism of neutrophil granulocytes, in the pathogenesis of acute myocardial infarction, stable coronary artery disease and arterial hypertension.
Techniques, methods & infrastructure
Flow cytometry, enzyme-linked immunosorbent assay, cell culture-based functional assays, immunohistochemistry and immunofluorescence, quantitative polymerase chain reaction.
Connection of experimental and laboratory measurements with clinical features and mortality of affected patients.
- Mangold, A. et al., 2014. Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct SizeNovelty and Significance. Circulation Research, 116(7), pp.1182-1192. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.116.304944.