Department of Medicine II (Division of Cardiology)
Position: Research Associate (Postdoc)
ORCID: 0000-0001-7625-3651
T +43 1 40400 73520
anna.ondracek@meduniwien.ac.at
Keywords
Cardiovascular Diseases; Coronary Thrombosis; Hypertension, Pulmonary; Innate Immunity; Myocardial Infarction; Neutrophil Activation; Thrombosis
Research group(s)
- Research group Irene Lang
Members:
Research interests
My main research topic focuses on innate immune mechanisms in cardiovascular disease. Particularly, we investigate neutrophil effector functions to understand formation of neutrophil extracellular traps (NETs) in acute coronary syndrome and stable coronary artery disease. We aim for a translational approach to elucidate the role of high lipid levels on the balance between NET formation and degradation.
Techniques, methods & infrastructure
At the Anna Spiegel Research Center we have the infrastructure to conduct research in translational biomedicine applying the most advanced techniques in molecular biology, flow cytometry, cell and tissue culture, immunohistochemistry, and immunofluorescence.
Selected publications
- Ondracek, A.S. et al. (2024) ‘Malondialdehyde-specific natural IgM inhibit NETosis triggered by culprit site–derived extracellular vesicles from myocardial infarction patients’, European Heart Journal, 46(10), pp. 926–939. Available at: https://doi.org/10.1093/eurheartj/ehae584.
- Ondracek, A.S. et al. (2022) ‘Physical Exercise Promotes DNase Activity Enhancing the Capacity to Degrade Neutrophil Extracellular Traps’, Biomedicines, 10(11), p. 2849. Available at: https://doi.org/10.3390/biomedicines10112849.
- Räber, L. et al. (2022) ‘Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction’, JAMA, 327(18), p. 1771. Available at: http://dx.doi.org/10.1001/jama.2022.5218.
- Hofbauer, T.M. et al. (2020) ‘Neutrophil Extracellular Traps Induce MCP-1 at the Culprit Site in ST-Segment Elevation Myocardial Infarction’, Frontiers in Cell and Developmental Biology, 8. Available at: https://doi.org/10.3389/fcell.2020.564169.
- Ondracek, A.S. et al. (2020) ‘Imbalance between plasma double-stranded DNA and deoxyribonuclease activity predicts mortality after out-of-hospital cardiac arrest’, Resuscitation, 151, pp. 26–32. Available at: https://doi.org/10.1016/j.resuscitation.2020.03.006.