Bionics; Brachial Plexus Neuropathies; Gait Disorders, Neurologic; Hand Injuries; Physical and Rehabilitation Medicine; Rehabilitation Centers; Upper Extremity Deformities, Congenital
The main focus of this laboratory is to explore the possibilities and limits of bionic reconstruction and has at its core interest the reconstruction and rehabilitation of patients with impaired extremity function. This goal is accomplished with a wide variety of surgical techniques of neuromuscular reconstruction alone or in combination with complex mechatronic devices. The various research projects focus on all aspects of reconstructive surgery, both from a clinical but also from a basic research perspective. This work has precipitated in different textbook chapters and is being published both in top journals in the field but also larger audience periodicals such as The Lancet and Science Translational Medicine and various Nature Group Periodicals.
Techniques, methods & infrastructure
We employ various animal models with the purpose of neuromuscular research. (Sprague-Dawley Rats, New Zealand White Rabbit, Goats, Minipigs) Techniques, such as force measurements, neural stimulation, retrograde neural tracing, histomorphometry, immunohistochemistry and solid platform in laboratory based research is established in our lab. We entertain lab space on the research space 8H, 1Q and the central research facility at Anna Spiegel.
- Bionic reconstruction to restore hand function after brachial plexus injury: a case series of three patients. Aszmann OC, Roche AD, Salminger S, Paternostro-Sluga T, Herceg M, Sturma A, Hofer C, Farina D. Lancet. 2015 May 30;385(9983):2183-9. doi: 10.1016/S0140-6736(14)61776-1. Epub 2015 Feb 25. PMID: 25724529
- Algorithm for bionic hand reconstruction in patients with global brachial plexopathies. Hruby LA, Sturma A, Mayer JA, Pittermann A, Salminger S, Aszmann OC. J Neurosurg. 2017 Jan 17:1-9. doi: 10.3171/2016.6.JNS16154. [Epub ahead of print] PMID: 28093018
- Elective amputation and bionic substitution restore functional hand use after critical soft tissue injuries. Aszmann OC, Vujaklija I, Roche AD, Salminger S, Herceg M, Sturma A, Hruby LA, Pittermann A, Hofer C, Amsuess S, Farina D. Sci Rep. 2016 Oct 10;6:34960. doi: 10.1038/srep34960. PMID: 27721419 Free PMC Article
- Functional and Psychosocial Outcomes of Hand Transplantation Compared with Prosthetic Fitting in Below-Elbow Amputees: A Multicenter Cohort Study. Salminger S, Sturma A, Roche AD, Hruby LA, Paternostro-Sluga T, Kumnig M, Ninkovic M, Pierer G, Schneeberger S, Gabl M, Chelmonski A, Jablecki J, Aszmann OC. PLoS One. 2016 Sep 2;11(9):e0162507. doi: 10.1371/journal.pone.0162507. eCollection 2016. PMID: 27589057 Free PMC Article
- Bionic limbs: clinical reality and academic promises. Farina D, Aszmann O. Sci Transl Med. 2014 Oct 8;6(257):257ps12. doi: 10.1126/scitranslmed.3010453. PMID: 25298319