Detail

Keywords

Diabetes Mellitus, Experimental; Magnetic Resonance Spectroscopy; Physiology

Research group(s)

• Substrate Metabolism
  Members:
  Michael Krebs
  Martin Krssak

Research interests

Non invasive assessment of ectopic lipid accumulation, glucose fluxes and ATP-handling in skeletal muscle, liver and myocardium by in vivo NMR spectroscopy.

Method development and integrative applications for the research of pathophysiology of diabetes mellitus and non-alcoholic fatty liver diseases as well as aging and sports physiology.

Techniques, methods & infrastructure

In vivo Magnetic Resonance Spectroscopy and Imaging: ¹³C, ³¹P, ¹H spectroscopy – muscle, liver, heart, brain – focus on glucose, lipid and energy metabolism

Fat/Water MRI, Dynamic contrast enhanced MRI, parameter selective MRI, molecular imaging

Broad experience with different MR systems (clinical, whole body experimental, animal) and field strength (1.5, 3, 7 & 9.4 T)

Cooperation with Centre of Excellence - High Field MR (Prof. Trattnig) and Preclinical Imaging Laboratory (Prof. Helbich), Department of Biomedical Imaging and Image guided Therapy (Radiodiagnostik und Nuklearmedizin).

Grants

• Preventing Aging by Exercise. Non-invasive MR based detection of metabolic and structural adaptation to exercise in the muscle and brain. (2022)
  Source of Funding: FWF (Austrian Science Fund), KLI-1122B
  Principal Investigator
• Non-invasive markers of muscular metabolic flexibility. (2020)
  Source of Funding: FWF (Austrian Science Fund), KLI-904B
  Principal Investigator
• Tracking Nutrient Metabolism and Cellular Partitioning by Multimodal Molecular Imaging (2019)
  Source of Funding: WWTF (Vienna Science and Technology Fund), LS19-46
  Principal Investigator
• Christian Doppler Laboratory for Clinical Molecular Imaging – MOLIMA (2017)
  Source of Funding: CDG (Christian Doppler Research Association), CD10277101
  Coordinator of the collaborative project
• Myokardiale Lipid- und Glykogenspeicherung bei Patienten mit Prädiabetes- und Type 2 Diabetes (2012)
  Source of Funding: OeNB (Oesterreichische Nationalbank), Jubiläumsfond 15363
  Principal Investigator
• Effects of impaired glucose homeostasis on cardiac function and lipid metabolism. Magnetic Resonance Spectroscopy and Imaging Study (2009)
  Source of Funding: OeNB (Oesterreichische Nationalbank), Jubiläumsfond 13249
  Principal Investigator

Selected publications

1. Krssak, M. et al. (1999) ‘Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study’, Diabetologia, 42(1), pp. 113–116. Available at: https://doi.org/10.1007/s001250051123.
2. Krssak, M. et al. (2004) ‘Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes’, Diabetes, 53(12), pp. 3048–3056. Available at: https://doi.org/10.2337/diabetes.53.12.3048.
3. Krššák, M. et al. (2020) ‘Proton magnetic resonance spectroscopy in skeletal muscle: Experts’ consensus recommendations’, NMR in Biomedicine, 34(5). Available at: https://doi.org/10.1002/nbm.4266.
4. Ehret, V. et al. (2024) ‘Evaluation of Hepatic Glucose and Palmitic Acid Metabolism in Rodents on High‐Fat Diet Using Deuterium Metabolic Imaging’, Journal of Magnetic Resonance Imaging [Preprint]. Available at: https://doi.org/10.1002/jmri.29437.
5. Klepochová, R. et al. (2024) ‘Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved 1H/31P MRS 7 T study’, Scientific Reports, 14(1). Available at: https://doi.org/10.1038/s41598-024-53221-x.