Department of Medicine III (Division of Endocrinology and Metabolism)
Position: Associate Professor
T +43 1 40400 37710
martin.krssak@meduniwien.ac.at
Keywords
Diabetes Mellitus, Experimental; Magnetic Resonance Spectroscopy; Physiology
Research group(s)
- Substrate Metabolism
Members:
Research interests
Non invasive assessment of ectopic lipid accumulation, glucose fluxes and ATP-handling in skeletal muscle, liver and myocardium by in vivo NMR spectroscopy.
Method development and integrative applications for the research of pathophysiology of diabetes mellitus and non-alcoholic fatty liver diseases as well as sports physiology.
Techniques, methods & infrastructure
In vivo multinuclear - 1H, 13C, and 31P - magnetic resonance spectroscopy in human and animal disease models
Cooperatiion with Centre of Excellence - High Field MR (Prof. Trattnig) and Preclinical Imaging Laboratory (Prof. Helbich), Department of Biomedical Imaging and Image guided Therapy (Radiodiagnostik und Nuklearmedizin).
Selected publications
- M. Krssak, K. Falk Petersen, A. Dresner, L. DiPietro, S. M. Vogel, D. L. Rothman, M. Roden, G. I. Shulman Intramyocellular Lipid Concentrations are Correlated with Insulin Sensitivity in Man: A 1H NMR Spectroscopy Study. Diabetologia 42: 113-116, 1999
- M. Krssak, A. Brehm, E. Bernroider, C. Anderwald, C. Dalla Man, P. Nowotny, C. Cobelli, G.W. Clilne, G.I. Shulman, W. Waldhäusl, M. Roden. Alteration in postprandial hepatic glycogen metabolism in type 2 diabetes mellitus. Diabetes 53(12): 3048-3056, 2004
- L. Valkovic, M. Gajdosik, S. Traussnigg, P. Wolf, M. Chmelik, W. Bogner, M. Krebs, M.Trauner, S. Trattnig, M. Krssak. Application of localized 31P MRS saturation transfer at 7T for measurement of ATP metabolism in the liver: reproducibility and first clinical application in patients with non-alcoholic fatty liver disease. Eur Radiol (2014) 24:1602,
- M. Gajdosik, G. Chadzynski, G. Hangel, V. Mlynarik, M. Chmelik, L. Valkovič, W. Bogner, R. Pohman, K. Scheffler, S. Trattnig, M. Krssak. Ultra-short TE STEAM and offline water signal subtraction improve quantification of lipids, choline-containing compounds and detection of fatty acid chains unsaturation in liver at 7 T. NMR Biomed. 2015 Oct;28(10):1283-93. doi: 10.1002/nbm.3382.
- M. Chmelik, L. Valkovič, P. Wolf, W. Bogner, M Gajdosik, S. Gruber, M. Krebs, S. Trattnig, and M. Krssak. Phosphatidylcholine contributes to in vivo 31P MRS signal from the human liver. Eur Radiol. 2015 Jan 11. [Epub ahead of print] DOI 10.1007/s00330-014-3578-y