Detail

Keywords

Adjuvants, Immunologic; Animal models; Antigens; Chlamydia Infections; Drug Administration Routes; Host-Pathogen Interactions; Immunity, Mucosal; Innate Immunity; Tetanus; Vaccinology

Research group(s)

• Inic-Kanada
  Head: Aleksandra Inic-Kanada
  Research Area: Chlamydia, Chlamydial infection, Host-pathogen interactions, Mucosal immunity, Mucosal vaccination, Vaccine development
  Members:
  Aleksandra Inic-Kanada

Research interests

My research focuses on a better understanding of the cross-talk between pathogen and epithelial-, structural-, and immune cells (host) required to mediate pathology vs. protection in chlamydial infection. Furthermore, my research interest lies in developing new approaches (antigens-, adjuvants-, route of immunization contexts) to optimize vaccinations.

Techniques, methods & infrastructure

Animal models: mice, guinea pig, pig. Various in vitro and ex vivo models for measurement of immune response after infection and vaccination.  

Selected publications

1. Inic-Kanada, A. et al., 2020. Water-filtered Infrared A and visible light (wIRA/VIS) treatment reduces Chlamydia caviae-induced ocular inflammation and infectious load in a Guinea pig model of inclusion conjunctivitis. Journal of Photochemistry and Photobiology B: Biology, 209, p.111953. Available at: http://dx.doi.org/10.1016/j.jphotobiol.2020.111953.
2. Stojanovic, M. et al. (2020) ‘Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia’, Vaccines, 8(4), p. 719. Available at: https://doi.org/10.3390/vaccines8040719.
3. Geissler, N. et al. (2023) ‘Obesity increases allergic airway inflammation that can be successfully treated by oral tolerance’, Allergy, 79(2), pp. 529–533. Available at: https://doi.org/10.1111/all.15989.
4. Inic-Kanada, A. et al., 2016. A Probiotic Adjuvant Lactobacillus rhamnosus Enhances Specific Immune Responses after Ocular Mucosal Immunization with Chlamydial Polymorphic Membrane Protein C D. M. Ojcius, ed. PLOS ONE, 11(9), p.e0157875. Available at: http://dx.doi.org/10.1371/journal.pone.0157875.
5. Frohns, A. et al. (2021) ‘Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs’, Journal of Photochemistry and Photobiology B: Biology, 224, p. 112306. Available at: https://doi.org/10.1016/j.jphotobiol.2021.112306.