Center for Anatomy and Cell Biology (Division of Cell and Developmental Biology)
Position: Research Associate (Postdoc)
ORCID: 0000-0003-2463-9223
T +43 1 40160 37731
cornelia.vesely@meduniwien.ac.at
Keywords
Allergy and Immunology; Colitis; High-Throughput Nucleotide Sequencing; Innate Immunity; MicroRNAs; RNA Editing
Research interests
Today, over 100 different chemical modifications of RNA have been described. The complexity and impact of these modifications in thousands of RNAs is adding another layer in regulating gene expression and sparked the field of epitranscriptomics with impact on biology and medicine. We are interested in the physiological consequences of A to I RNA editing within the context of human diseases, currently with a focus on inflammatory bowel diseases, utilizing mouse models and modern sequencing technologies.
Selected publications
- Mannion, N.M. et al., 2014. The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA. Cell Reports, 9(4), pp.1482–1494. Available at: http://dx.doi.org/10.1016/j.celrep.2014.10.041.
- Vesely, C. et al., 2014. ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain. Nucleic Acids Research, 42(19), pp.12155–12168. Available at: http://dx.doi.org/10.1093/nar/gku844.
- Vesely, C. et al., 2012. Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs. Genome Research, 22(8), pp.1468–1476. Available at: http://dx.doi.org/10.1101/gr.133025.111.
- Flanagan, K. et al. (2025) ‘Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicron’, mBio. Edited by C.M. Fraser, 16(3). Available at: https://doi.org/10.1128/mbio.03928-24.
- Vesely, C. et al. (2016) ‘Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia’, Leukemia, 31(7), pp. 1491–1501. Available at: https://doi.org/10.1038/leu.2016.365.