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Diana Mechtcheriakova
Diana Mechtcheriakova, Assoc.-Prof. Priv. Doz. Dr. Dipl.-Ing.Head of Research Group Molecular Systems Biology and Pathophysiology

Center for Pathophysiology, Infectiology and Immunology (Institute of Pathophysiology and Allergy Research)
Position: Associate Professor

ORCID: 0000-0002-8737-3592
T +43 1 40400 28600
diana.mechtcheriakova@meduniwien.ac.at

Further Information

Keywords

Adaptive Immunity; Artificial Intelligence; B-Lymphocytes; Digital Histopathology; Sphingolipids; Systems Biology

Research group(s)

Research interests

My long-term research interest is to expand the knowledge on cellular checkpoints, which redirect the physiologically balanced system towards pathological situations leading to development and progression of multifactorial diseases such as aberrant immunity, chronic inflammation and cancer.

Our scientific directions are systems biology and systems medicine as part of the global concept of personalized medicine. Special interests refer to development of systems biology approaches, AI-powered solutions, with major focus on B-cell biology, immuno-oncology, lymphoid structures, the AID/APOBEC-associated biological events and cellular sphingolipid/lysophosphatidate system - in immunity and cancer with translational perspectives.

Techniques, methods & infrastructure

Multimodular systems biology-driven strategies: (i) quantitative spatial tissue image cytometry on single-cell level on whole-slide digital histological images, (ii) spatial transcriptomics on the basis of FFPE tissue specimens, (iii) compendium-wide integrative data analysis and the clinical relevance, and (iv) AI-powered solutions in biomedical research. 


Selected publications

  1. Meshcheryakova, A. et al. (2021) ‘AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19’, Frontiers in Immunology, 12. Available at: https://doi.org/10.3389/fimmu.2021.690416.
  2. Mungenast, F. et al. (2020) ‘The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer’, Cancers, 12(11), p. 3117. Available at: https://doi.org/10.3390/cancers12113117.
  3. Meshcheryakova, A. et al. (2019) ‘Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer’, Computational and Structural Biotechnology Journal, 17, pp. 537–560. Available at: https://doi.org/10.1016/j.csbj.2019.04.004.
  4. Svoboda, M. et al. (2016) ‘AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer’, BMC Genomics, 17(1). Available at: https://doi.org/10.1186/s12864-016-3001-y.
  5. Meshcheryakova, A. et al. (2014) ‘B Cells and Ectopic Follicular Structures: Novel Players in Anti-Tumor Programming with Prognostic Power for Patients with Metastatic Colorectal Cancer’, PLoS ONE. Edited by J.-P. Vartanian, 9(6), p. e99008. Available at: https://doi.org/10.1371/journal.pone.0099008.