Detail

Keywords

Alkaline Phosphatase; Anabolic Agents; Bone Diseases; Calcium; Chondrocytes; Growth Plate; Hypophosphatasia; Osteogenesis Imperfecta; Osteoporosis; Phosphorous Acids; Rickets, Hypophosphatemic

Research group(s)

• Pediatric Endocrinolgy and Osteology
  Members:
  Adalbert Raimann
• Vienna Bone and Growth Center
  Research Area: Rare bone and growth disorders
  Members:
  Adalbert Raimann

Research interests

Bone and growth plate research

• Mechanisms of linear growth regulation
• Local phosphate metabolism
• X-linked hypophosphatemic rickets
• Osteogenesis imperfecta
• Pediatric osteoporosis

Techniques, methods & infrastructure

• 3D chondrocyte culture
• Primary chondrocyte cultures
• Porcine model system
• RT-PCR, ddPCR, ELISA, Western Blot, IHC

Selected publications

1. Raimann, A. et al., 2020. Elevation of phosphate levels impairs skeletal myoblast differentiation. Cell and Tissue Research, 382(2), pp.427–432. Available at: http://dx.doi.org/10.1007/s00441-020-03254-1.
2. Raimann, A. et al., 2013. Fibroblast Growth Factor 23 and Klotho Are Present in the Growth Plate. Connective Tissue Research, 54(2), pp.108–117. Available at: http://dx.doi.org/10.3109/03008207.2012.753879.
3. Raimann, A. et al., 2020. Decreased Compressional Sound Velocity Is an Indicator for Compromised Bone Stiffness in X-Linked Hypophosphatemic Rickets (XLH). Frontiers in Endocrinology, 11. Available at: http://dx.doi.org/10.3389/fendo.2020.00355.
4. Raimann, A. et al., 2017. A journey through growth plates: tracking differences in morphology and regulation between the spine and the long bones in a pig model. The Spine Journal, 17(11), pp.1674–1684. Available at: http://dx.doi.org/10.1016/j.spinee.2017.06.001.
5. Mindler, G.T. et al., 2020. Disease-specific gait deviations in pediatric patients with X-linked hypophosphatemia. Gait & Posture, 81, pp.78–84. Available at: http://dx.doi.org/10.1016/j.gaitpost.2020.07.007.