Detail

Keywords

-gender differences; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Endocrinology; Gender Identity; Inflammation; Obesity; Sex Characteristics; Transgendered Persons

Research group(s)

• Gender Medicine Unit
  Head: Alexandra Kautzky-Willer
  Members:
  Teresa Gisinger
  Carola Deischinger
  Alexandra Kautzky-Willer
  Michael Leutner

Research interests

• Endocrinology
• Gestational diabetes and fetal programming
• Gender aspects of obesity
• Gender aspects of metabolic syndrome
• Gender aspects of type 2 diabetes
• Gender aspects of type 1 diabetes/autoimmunity
• Gender aspects of insulin resistance and beta cell function: Changes in pathogenesis of and interaction with different disease processes
• Gender aspects of inflammation, adipokines, endothelial dysfunction

Techniques, methods & infrastructure

- Functional tests, insulin sensitivity, insulin secretion, incretins;
- Glucose monitoring
- Minimal modeling
- Spectroscopy

Grants

• GOING-FWD Gender Outcomes INternational Group: to Further Well-being Development (2019)
  Source of Funding: FWF (Austrian Science Fund), GENDER-NET Plus ERA-NET Cofund
  Principal Investigator
• Optimal gender-specific treatment paths on healthcare multiplex networks (2017)
  Source of Funding: WWTF (Vienna Science and Technology Fund), Mathematics and…
  Principal Investigator
• Epigenetik-basierte Typ-2-Diabetes Diagnostik aus Speichel und Blut (2015)
  Source of Funding: FFG (Austrian Research Promotion Agency), FEMtech
  Principal Investigator
• DIABgender: Gender-specific Diabetes Self-management (2014)
  Source of Funding: FFG (Austrian Research Promotion Agency), FEMtech FTI
  Principal Investigator
• DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention (2010)
  Source of Funding: EU, FP7
  Principal Investigator

Selected publications

1. Tomic, D. et al. (2022) ‘Lifetime risk, life expectancy, and years of life lost to type 2 diabetes in 23 high-income jurisdictions: a multinational, population-based study’, The Lancet Diabetes & Endocrinology, 10(11), pp. 795–803. Available at: http://dx.doi.org/10.1016/s2213-8587(22)00252-2.
2. Paolino, M. et al. (2020) ‘RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy’, Nature, 589(7842), pp. 442–447. Available at: http://dx.doi.org/10.1038/s41586-020-03071-0.
3. Leutner, M. et al. (2019) ‘Diagnosis of osteoporosis in statin-treated patients is dose-dependent’, Annals of the Rheumatic Diseases, 78(12), pp. 1706–1711. Available at: http://dx.doi.org/10.1136/annrheumdis-2019-215714.
4. Harreiter, J. et al. (2019) ‘Nutritional Lifestyle Intervention in Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-β-Hydroxybutyrate, and Fasting Glucose Concentrations: A Secondary Factorial Analysis of the European Multicenter, Randomized Controlled DALI Lifestyle Intervention Trial’, Diabetes Care, 42(8), pp. 1380–1389. Available at: http://dx.doi.org/10.2337/dc19-0418.
5. Kautzky-Willer, A., Harreiter, J. and Pacini, G. (2016) ‘Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus’, Endocrine Reviews, 37(3), pp. 278–316. Available at: http://dx.doi.org/10.1210/er.2015-1137.