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Priv.-Doz. Mag. Dr. Alfred Gugerell

Department of Thoracic Surgery
Position: Research Assistant

ORCID: 0000-0002-5178-9967
T +43 1 40400 69790


Cardiology; Clinical Trial, Phase II; Culture Media, Conditioned; Diabetic Foot; Fibrin; Imaging, Three-Dimensional; Quality Control; Regeneration; Regenerative Medicine; Tissue Engineering; Wound Healing

Research interests

As a biologist (anthropology) my scientific background lies in the cell biology and molecular biology. Currently, I am responsible for clinical development and act as internal project manager of the clinical phase II study MARSYAS II. Prior to that, I worked in the field of cellular transformation in acute myocardial infarction in porcine in vivo models (Department of Cardiology) and could gain experiences in soft tissue-engineering and wound-healing research (Department of Plastic and Reconstructive Surgery at the Medical University of Vienna). My PhD thesis discusses the application of fibrin sealant in wound healing (Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Baxter Bioscience / Biosurgery).

Techniques, methods & infrastructure

Primary cell culture, Histology, Imaging, Flow cytometry, RNA, Proteins

Regulatory Affairs, Clinical Trials, Product Science, Quality Management, Data protection

Selected publications

  1. Gugerell, A. et al., 2019. Viral safety of APOSEC: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine. Blood Transfusion, 2019 Feb 21
  2. Gugerell, A. et al. (2021) ‘Safety and clinical efficacy of the secretome of stressed peripheral blood mononuclear cells in patients with diabetic foot ulcer—study protocol of the randomized, placebo-controlled, double-blind, multicenter, international phase II clinical trial MARSYAS II’, Trials, 22(1). Available at:
  3. Gugerell, A. et al., 2014. Thrombin as important factor for cutaneous wound healing: Comparison of fibrin biomatrices in vitro and in a rat excisional wound healing model. Wound Repair Regen, 22(6), pp.740-748. Available at:
  4. Laggner, M. et al., 2020. Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products. Stem Cell Research & Therapy, 11(1). Available at:
  5. Gugerell, A. et al., 2012. High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes. Journal of Biomedical Materials Research Part A, 100A(5), pp.1239-1247. Available at: