Detail

Keywords

Cartilage; Diffusion Magnetic Resonance Imaging; Film Dosimetry; Magnetic Resonance Imaging; Microscopy; Multimodal Imaging; Phantoms, Imaging; Polymers; Quality Control; Radiation Oncology; Tendons; Ultrahigh field MRI

Research group(s)

• Magnetic Resonance Microimaging and -Microscopy
  Research Area: Magnetic Resonance (MR)-micro-imaging and -microscopy on a human high-field MR scanner: Implementations (Hardware), quality control and Bio-medical applications
  Members:
  Andreas Berg

Research interests

Parameter selective Magnetic Resonance (MR) Micro-Imaging and MR-Microscopy:

1.) Hardware and Software Development

2.) Quality control

3.) Applications:

• Polymer-gel-dosimetry for radiation therapy
• Imaging of the MR-invisible in clinical imaging (e.g. hard tissue, teeth)
• Imaging of Biocompatible material (e.g. plastics) and its degradation
• MR-based-histology
• High-resolution invivo µ-imaging
• New MR-microscopy applications

Techniques, methods & infrastructure

1.) Hardware:

• High-field (B = 7T) Magnetic Resonance Imaging (MRI) -scanner;
• Magnetic Resonance Microscopy insert;
• Simple chemical lab

2.) Measurement techniques:

• Parameter selective imaging for different contrasts:
• spin density, T2, T1, diffusivity, fat- + water-saturation, Magnetization transfer,..
• Ultrashort time imaging (UTE) of rigid tissue and polymer imaging ( Rausch et. al. European Patent Office publication server 2022 )

3.) Special techniques:

• Magnetic Resonance microscopy and micro-imaging
• Ultrashort detection time imaging (UTE)
• Polymer gel manufacturing and MR-imaging based high resolution 3D dosimetry

Selected publications

1. Berg, A.G. and Börner, M. (2023) ‘A phantom for the quantitative determination and improvement of the spatial resolution in slice-selective 2D-FT magnetic resonance micro-imaging and -microscopy based on Deep X-ray Lithography (DXRL)’, Frontiers in Physics, 11. Available at: http://dx.doi.org/10.3389/fphy.2023.1144112.
2. A. Berg, M. Stoiber, X. Deligianni, O. Bieri; T2*-mapping of tendon µ-structure changes after mechanical load in an adult bovine animal model using vTE pulse sequences: the role of resolution up to microscopic scale in quantification; Magnetic Resonance Materials in Physics, Biology and Medicine 30 (Suppl 1): S106-S107 (2017)
3. Khan, M. et al. (2019) ‘Basic Properties of a New Polymer Gel for 3D-Dosimetry at High Dose-Rates Typical for FFF Irradiation Based on Dithiothreitol and Methacrylic Acid (MAGADIT): Sensitivity, Range, Reproducibility, Accuracy, Dose Rate Effect and Impact of Oxygen Scavenger’, Polymers, 11(10), p. 1717. Available at: http://dx.doi.org/10.3390/polym11101717.
4. Hager, B., Schreiner, M.M., Walzer, S.M., Hirtler, L., Mlynarik, V., Berg, A., Deligianni, X., Bieri, O., Windhager, R., Trattnig, S. and Juras, V. (2022), Transverse Relaxation Anisotropy of the Achilles and Patellar Tendon Studied by MR Microscopy. J Magn Reson Imaging, 56: 1091-1103. https://doi.org/10.1002/jmri.28095
5. 5. A. Berg, G. Heilemann, D. Georg MR-µ-imaging based 3-dimensional-polymer gel dosimetry in comparison to 2D-film and 1D-diamond dosimetry of mm-sized photon pencil beams; Biomedical Engineering-Biomedizinische Technik 62(s1) S519 (sept 2017); https://doi.org/10.1515/bmt-2017-5099