Detail

Keywords

Diabetes Mellitus; Diabetes, Gestational; Dyslipidemias; Endocrinology; Glucose Metabolism Disorders; Osteoporosis

Research group(s)

• Gender Medicine Unit
  Head: Alexandra Kautzky-Willer
  Members:
  Teresa Gisinger
  Carola Deischinger
  Alexandra Kautzky-Willer
  Michael Leutner

Research interests

My current research investigates the relationship between cholesterol-lowering drugs such as statins and the development of hormone-related diseases. Statins inhibit HMG-CoA reductase, the main enzyme in the synthesis of cholesterol. Cholesterol is the basic substance for the synthesis of vital hormones such as testosterone or oestrogen. I am therefore currently investigating whether there is a dose-dependent relationship between statins and osteoporosis.

Further research interests are:

• Endocrinology and metabolism
• Hyperlipidemia
• Diabetes mellitus
• Gender Medicine
• Gestational diabetes

Techniques, methods & infrastructure

• Big data
• Prospective clinical studies
• Functional tests measuring insulin secretion, insulin sensitivity, beta-cell function and incretins
• Continuous glucose monitoring
• Magnetic resonance spectroscopy
• Intestinal microbiome 

Selected publications

1. Leutner, M. et al., 2019. Diagnosis of osteoporosis in statin-treated patients is dose-dependent. Annals of the Rheumatic Diseases, 78(12), pp.1706–1711. Available at: http://dx.doi.org/10.1136/annrheumdis-2019-215714.
2. Leutner, M. et al., 2019. A Sex-Specific Analysis of the Predictive Value of Troponin I and T in Patients With and Without Diabetes Mellitus After Successful Coronary Intervention. Frontiers in Endocrinology, 10. Available at: http://dx.doi.org/10.3389/fendo.2019.00105.
3. Leutner, M. et al., 2019. Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of Roux-en-Y gastric bypass operation. Metabolism, 91, pp.10–17. Available at: http://dx.doi.org/10.1016/j.metabol.2018.10.006.
4. Leutner, M. et al., 2018. Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects. International Journal of Endocrinology, 2018, pp.1–8. Available at: http://dx.doi.org/10.1155/2018/5406128.
5. Leutner, M. et al., 2016. Clinical and metabolic characteristics of treated hyperlipidemic patients additionally affected by subclinical hyperglycemia. Lipids in Health and Disease, 15(1). Available at: http://dx.doi.org/10.1186/s12944-016-0180-0.