Detail

Keywords

Acute Lung Injury; Allergy and Immunology; Cytokines; Macrophage Activation; Pneumonia; SARS Virus; Sepsis; Streptococcus

Research group(s)

• Infection Biology Research Lab
  Head: Sylvia Knapp
  Research Area: Endogenous modulators of inflammation; Macrophage plasticity in bacterial lung infections; Co- and Super-Infection
  Members:
  Sylvia Knapp
  Riem Gawish
  Stefanie Widder

Research interests

I am investigating the molecular mechanisms which drive immunopathology-induced tissue damage and try to identify the key determinants of recovery or organ failure in critical disease.

Techniques, methods & infrastructure

• Mouse models of infection and sepsis, sterile inflammation and chronic viral infection
• All standard Molecular Biology techniques

Selected publications

1. Gawish, R. et al. (2022) ‘A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4’, eLife, 11. Available at: https://doi.org/10.7554/elife.78291.
2. Watzenboeck, M.L. et al. (2021) ‘Multi-omics profiling predicts allograft function after lung transplantation’, European Respiratory Journal, 59(2), p. 2003292. Available at: https://doi.org/10.1183/13993003.03292-2020.
3. Gawish, R. et al. (2022) ‘ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology’, eLife, 11. Available at: https://doi.org/10.7554/elife.74623.
4. Lang, C. et al. (2020) ‘Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient’, The Lancet Respiratory Medicine, 8(10), pp. 1057–1060. Available at: https://doi.org/10.1016/s2213-2600(20)30361-1.
5. Gawish, R. et al. (2019) ‘Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1’, Cell Reports, 26(9), pp. 2394-2406.e5. Available at: https://doi.org/10.1016/j.celrep.2019.02.017.