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Severin Mairinger

Department of Clinical Pharmacology
Position: Research Associate (Postdoc)

ORCID: 0000-0001-5094-9351


ATP-Binding Cassette Transporters; Blood-Brain Barrier; Drug Development; Drug Interactions; Lung; Membrane Transport Proteins; Pharmacokinetics; Pharmacology, Clinical; Positron-Emission Tomography; Tissue Distribution

Research group(s)

Selected publications

  1. Mairinger, S. et al. (2024) ‘Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates’, EJNMMI Radiopharmacy and Chemistry, 9(1). Available at:
  2. Mairinger, S. et al. (2023) ‘[11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier’, Journal of Cerebral Blood Flow & Metabolism, 44(1), pp. 142–152. Available at:
  3. Mairinger, S. et al. (2022) ‘Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats’, Journal of Controlled Release, 349, pp. 109–117. Available at:
  4. Mairinger, S. et al. (2022) ‘Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition’, Expert Opinion on Drug Delivery, 19(12), pp. 1561–1575. Available at:
  5. Mairinger, S. et al. (2020) ‘Assessing the Activity of Multidrug Resistance–Associated Protein 1 at the Lung Epithelial Barrier’, Journal of Nuclear Medicine, 61(11), pp. 1650–1657. Available at: