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Christian  Pifl
Ao.Prof. Dr. Christian Pifl

Center for Brain Research (Division of Molecular Neurosciences)
Position: Associate Professor


Catecholamine Plasma Membrane Transport Proteins; Neurochemistry; Neuropharmacology; Parkinson Disease

Techniques, methods & infrastructure

  • HPLC with electrocehmical detecion for quantitative determination of noradrenaline, dopamine, 3,4-dihydroxyphenyl acetic acid, homovanillic acid, serotonin, 5-hydroxyindol acetic acid.
  • HPLC with fluorometric detection after precolumn derivatization for quantitative determination of aspartate, glutamate, glutamine, asparagine, glycine, serine, alanine, threonine, taurine, GABA.
  • Radioligand binding assays, transport and release (superfusion) assays on synaptosomes, synaptic vesicles, transfected cells.
  • Radiochemical assays for glutamic acid decarboxylase, choline acetyl transferase.

Selected publications

  1. Bhat, S. et al. (2023) ‘A mechanism of uncompetitive inhibition of the serotonin transporter’, eLife, 12. Available at:
  2. Hörtnagl, H. et al. (2019) ‘Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain’, Journal of Neurochemistry, 152(6), pp. 650–662. Available at:
  3. Pifl, C. et al. (2014) ‘Is Parkinson’s Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum’, Journal of Neuroscience, 34(24), pp. 8210–8218. Available at:
  4. Pifl, C., Reither, H. and Hornykiewicz, O. (2015) ‘The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter’, European Journal of Pharmacology, 755, pp. 119–126. Available at:
  5. Sitte HH, Huck S, Reither H, Boehm S, Singer EA, Pifl C (1998) Carrier-mediated release, transport rates and charge transfer induced by amphetamine, tyramine and dopamine in mammalian cells transfected with the human dopamine transporter J Neurochem, 71: 1289-1297