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Dietmar Herndler-Brandstetter
Dietmar Herndler-Brandstetter, PhDGroup Leader

Center for Cancer Research, Comprehensive Cancer Center
Position: Assistant Professor

ORCID: 0000-0003-0987-0208
T +43 1 40160 - 57577

Further Information


Colorectal Neoplasms; Immune System; Immunotherapy; Tumor Microenvironment

Research interests

  • Humanized mouse models for translational cancer research and immunotherapy
  • Stromal regulation of immune cell development and anti-tumor immunity
  • Long noncoding RNA regulation of adaptive and anti-tumor immunity

Techniques, methods & infrastructure

  • Next-generation humanized mouse models (MISTRG-6)
  • A collection of 20+ colorectal cancer patient-derived tumor xenografts (CRC-PDXs)
  • Cancer immunotherapies
  • Fate reporter and conditional knockout mouse models
  • scRNA-seq
  • 35+ color full spectrum flow cytometry (Cytek Aurora)
  • Multiplex immunohistochemistry (mIHC)


Selected publications

  1. Herndler-Brandstetter*, Ishigame* et al. (2018) KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity, 48(4), pp.716-729.e8. Available at:
  2. Ring*, Herndler-Brandstetter*, Weiskopf* et al. (2017) Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. PNAS, 114(49), pp.E10578-E10585. Available at:
  3. Herndler-Brandstetter*, Shan* et al. (2017) Humanized mouse model supports development, function, and tissue residency of human natural killer cells. PNAS, 114(45), pp.E9626-E9634. Available at:
  4. Chen, A., Neuwirth, I. and Herndler-Brandstetter, D. (2023) ‘Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice’, Cancers, 15(11), p. 2989. Available at:
  5. Moritsch et al. (2022) ‘Tyk2 is a tumor suppressor in colorectal cancer’, OncoImmunology, 11(1). Available at: