Cardiovascular Diseases; Immune System
Heart attacks are the main causes of death worldwide. The main underlying pathology of this devastating condition is atherosclerosis, a lipid-driven chronic inflammatory disease that leads to the formation of an atherosclerotic plaque in large and medium size arteries. Plaque rupture or erosion triggers thrombus formation, which restricts blood flow in the artery, thereby limiting oxygen supply to the heart muscle and consequently causing myocardial cell necrosis. B cells play a cardinal role both in atherosclerosis and post myocardial infarction injury. My research aims to dissect the mechanisms by which B cells impact these pathologies and identify the molecular machinery that governs the altered B cell responses in these settings.
- Tsiantoulas, D. et al., 2018. B Cell–Activating Factor Neutralization Aggravates Atherosclerosis. Circulation, 138(20), pp.2263–2273. Available at: http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032790.
- Tsiantoulas, D. et al., 2017. Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency. Circulation Research, 120(1), pp.78–84. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.116.309606.
- Tsiantoulas, D. et al., 2015. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. Journal of Lipid Research, 56(2), pp.440–448. Available at: http://dx.doi.org/10.1194/jlr.P054569.
- Tsiantoulas, D. et al., 2014. B Cells and Humoral Immunity in Atherosclerosis. Circulation Research, 114(11), pp.1743–1756. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.113.301145.
- Sage, A.P. et al., 2018. The role of B cells in atherosclerosis. Nature Reviews Cardiology, 16(3), pp.180–196. Available at: http://dx.doi.org/10.1038/s41569-018-0106-9.