Detail

Keywords

Adaptation, Physiological; Adaptation, Psychological; Allostasis; Biological Evolution; Cell Differentiation; Choice Behavior; Consummatory Behavior; Developmental Biology; Fertility; Gene Regulatory Networks; Hormones; Hypothalamus; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Metabolism; Mutation; Reproduction; Sequence Homology; Social Behavior; Transcription regulation

Research interests

My research centers on the neurodevelopment and function of the hypothalamus, employing single-cell RNA sequencing to elucidate the roles of transcriptional regulation in neuronal and glial differentiation. My work addresses: 1) Molecular mechanisms of hypothalamus development impacting key life functions; 2) Transcription factor cascades influencing neurogenesis and brain structure; and 3) Genomic associations with neuropsychiatric and endocrinological disorders for potential clinical applications. My research ambitiously synthesizes phenotypical and medical data across modalities to decode developmental, ontogenic, and trans-generational impact on metabolism, fertility, reproductive health, neuroendocrine and neuropsychiatric disorders, and mental and physical performance. I aim to translate molecular insights into tangible clinical outcomes, informing everyday life protocols and potentially extending lifespan, thereby contributing to the discovery of therapeutic strategies.

Techniques, methods & infrastructure

I delve into single-cell sequencing and other advanced experimental and computational techniques.

Selected publications

1. Hevesi Z., Bakker J., Tretiakov E. O., et al. (2024) ‘Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice’, Nature Communications, 15(1). Available at: https://doi.org/10.1038/s41467-024-47054-5.
2. Mikhaylova A. G., Mikhailova A. A., Ushakova K., Tretiakov E. O.* et al. (2022) ‘A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand’, Nucleic Acids Research, 50(18), pp. 10264–10277. Available at: https://doi.org/10.1093/nar/gkac779.
3. Ahmed, M. et al. (2022) ‘A hypothalamic pathway for Augmentor α–controlled body weight regulation’, Proceedings of the National Academy of Sciences, 119(16). Available at: https://doi.org/10.1073/pnas.2200476119.
4. Romanov R. A. and Tretiakov E. O.* et al. (2020) ‘Molecular design of hypothalamus development’, Nature, 582(7811), pp. 246–252. Available at: https://doi.org/10.1038/s41586-020-2266-0.
5. Orthofer, M. et al. (2020) ‘Identification of ALK in Thinness’, Cell, 181(6), pp. 1246-1262.e22. Available at: https://doi.org/10.1016/j.cell.2020.04.034.