Irene Hernandez-Lozano
Department of Clinical Pharmacology
Position: Research Associate (Postdoc)
ORCID: 0000-0002-3700-7690
T +43 1 40400 73752
irene.hernandezlozano@meduniwien.ac.at
Keywords
Drug Interactions; Kidney; Liver; Membrane Transport Proteins; Pharmacokinetics; Pharmacology; Pharmacology, Clinical; Positron-Emission Tomography; Tissue Distribution
Research group(s)
- Section of Clinical Pharmacokinetics / Pharmacogenetics and Imaging
Head: Markus Zeitlinger
Research Area: Our main focus is the study of the drug distribution process by employing techniques to measure target site distribution directly, i.e. PET or microdialysis.
Members: - Translational Pharmacokinetic Imaging
Head: Oliver Langer
Members:
Selected publications
- Hernández-Lozano, I. et al. (2022) ‘PET imaging to assess the impact of P-glycoprotein on pulmonary drug delivery in rats’, Journal of Controlled Release, 342, pp. 44–52. Available at: http://dx.doi.org/10.1016/j.jconrel.2021.12.031.
- Hernández-Lozano, I. et al. (2021) ‘Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice’, European Journal of Pharmaceutical Sciences, 163, p. 105854. Available at: http://dx.doi.org/10.1016/j.ejps.2021.105854.
- Hernández-Lozano, I. et al. (2021) ‘Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice’, Pharmaceutical Research, 38(1), pp. 127–140. Available at: http://dx.doi.org/10.1007/s11095-021-03002-2.
- Hernández Lozano, I. et al. (2019) ‘Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [11C]Tariquidar and PET in Humans and Mice’, Molecular Pharmaceutics, 17(1), pp. 316–326. Available at: http://dx.doi.org/10.1021/acs.molpharmaceut.9b01060.
- Hernández Lozano, I. et al. (2019) ‘Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography’, The AAPS Journal, 21(4). Available at: http://dx.doi.org/10.1208/s12248-019-0323-0.