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Katharina Krenn
Priv.-Doz. Dr. Katharina Krenn, DESAHead of the lung research group (AG Lunge)

Department of Anaesthesia, Intensive Care Medicine and Pain Medicine (Division of General Anaesthesia and Intensive Care Medicine)
Position: Consultant

ORCID: 0000000269509361
T +43 1 4040041020


Acute Lung Injury; Clinical Trial; Intensive Care; Renin-Angiotensin System

Research group(s)

Research interests

My research focuses are clinical trials in critical care medicine, acute lung injury/acute respiratory distress syndrome and the renin-angiotensin-system in critical illness and the perioperative period. Currently, my research group is participating in the multicenter phase IIb trial on AP301/solnatide as inhalation therapy for ARDS.


  • The angiotensin metabolite profile after subarachnoid hemorrhage (2021)
    Source of Funding: FWF (Austrian Science Fund), KLIF
    Principal Investigator

Selected publications

  1. Krenn, K. et al., 2017. Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial. Critical Care, 21(1). Available at:
  2. Schmid, B. et al. (2021) ‘Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial’, Trials, 22(1). Available at:
  3. Mao, X. et al. (2022) ‘Tidal Volume–Dependent Activation of the Renin-Angiotensin System in Experimental Ventilator-Induced Lung Injury*’, Critical Care Medicine, 50(9), pp. e696–e706. Available at:
  4. Mao, X. et al. (2023) ‘Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice’, Frontiers in Physiology, 14. Available at: