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Klaus Ulrich Klein
Assoc.-Prof. PD Dr. med. Klaus Ulrich Klein, MD

Department of Anaesthesia, Intensive Care Medicine and Pain Medicine (Division of General Anaesthesia and Intensive Care Medicine)
Position: Associate Professor

ORCID: 0000-0001-7446-0542
T +43 1 40400 41020


Anesthesia; Critical Care; Patient Safety; Perioperative Medicine

Research interests

Anesthesia, Critical Care Medicine, Perioperative Medicine, Perioperative Outcome, Organ Protection, Perioperative Lung Injury, Perioperative Brain Injury, Perioperative Myocardial Injury, Organ Crosstalk, Argon Preconditioning, Oxygen Oscillations, Hyperoxia, Oxygen Oscillations, Ischemia Reperfusion Injury, Patient Safety

Techniques, methods & infrastructure

Ultra-rapid oxygen sensing technology, fluorescence quenching of oxygen technology, near infrared spectroscopy, electrical impedance tomography, confocal laser scanning microscopy, rt-PCR, ELISA, Westernblot, Immunofluorescence, Microscopy, Histology, FACS, big data analysis, heart rate variability analysis


  • Rapid PO2-changes as a mechanism of lung injury (2015)
    Source of Funding: Gottfried and Vera Weiss (FWF), Stand-Alone Projects
    Principal Investigator
  • Identifying the protective effects of the noble gas argon on human umbilical vein endothelial cells and human adult cardiomyocytes (2014)
    Source of Funding: Medical Scientific Fund of the Mayor of the City of Vienna,
    Principal Investigator

Selected publications

  1. Wu J, Stefaniak J, Hafner C, Schramel JP, Kaun C, Wojta J, Ullrich R, Tretter VE, Markstaller K, Klein KU, 2015. Intermittent Hypoxia Causes Inflammation and Injury to Human Adult Cardiac Myocytes. Anesth Analg. [Epub ahead of print].
  2. Klein, K.U. et al., 2015. Systemic PaO2 Oscillations Cause Mild Brain Injury in a Pig Model. Critical Care Medicine, p.1. Available at:
  3. Wu J, Hafner C, Schramel JP, Kaun C, Krychtiuk KA, Wojta J, Boehme S, Ullrich R, Tretter EV, Markstaller K, Klein KU, 2015. Cyclic and constant hyperoxia cause inflammation, apoptosis and cell death in human umbilical vein endothelial cells. Acta Anaesthesiol Scand. [Epub ahead of print].
  4. Gruber, S. et al., 2015. Real-time in-vivo imaging of pulmonary capillary perfusion using probe-based confocal laser scanning endomicroscopy in pigs. European Journal of Anaesthesiology, 32(6), pp.392-399. Available at:
  5. Klein, K.U. et al., 2012. Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic recruitment and derecruitment. British Journal of Anaesthesia, 110(2), pp.266-273. Available at: