Biological Psychiatry; DNA Methylation; Genetic Association Studies; Neuropsychiatry
My main interest is to understand better how psychiatric disease phenotypes and psychopharmacologic therapies affect the methylation status at the BDNF gene, which is an important candidate gene in affective disorders. My major research experience, though, has come through an ongoing research project "Vienna Study on Genetics of Suicidal Behaviour in Affective Disorders" (KLIF 220; principal investigator: Priv.-Doz. Dr. Alexandra Schosser, PhD.). In the context of my PhD I'm working in the field of psychiatric (epi-)genetics on my doctoral thesis, "BDNF - Epigenetic regulation in MDD". I analysed the methylation status of one BDNF gene promoter in a large sample of 600 affective disorder patients and healthy control subjects.
Techniques, methods & infrastructure
- Combined Bisulfite Restriction Analysis (CORBRA)
- Bisulfite Conversion/Methylation specific Real-Time-quantitative-PCR (qPCR)
- Carlberg, L. et al., 2014. Brain-derived neurotrophic factor (BDNF) Epigenetic regulation in unipolar and bipolar affective disorder. Journal of Affective Disorders, 168, pp.399-406. Available at: http://dx.doi.org/10.1016/j.jad.2014.07.022.
- Carlberg, L. et al., 2014. Association study of CREB1polymorphisms and suicidality in MDD: results from a European multicenter study on treatment resistant depression. International Journal of Neuroscience, 125(5), pp.336-343. Available at: http://dx.doi.org/10.3109/00207454.2014.936554.
- Bernegger, A. et al., 2015. Influence of Sex on Suicidal Phenotypes in Affective Disorder Patients with Traumatic Childhood Experiences M. Mazza, ed. PLOS ONE, 10(9), p.e0137763. Available at: http://dx.doi.org/10.1371/journal.pone.0137763.
- Boraska, V. et al., 2014. A genome-wide association study of anorexia nervosa. Molecular Psychiatry, 19(10), pp.1085-1094. Available at: http://dx.doi.org/10.1038/mp.2013.187.
- Hinney, A. et al., 2016. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22(2), pp.192-201. Available at: http://dx.doi.org/10.1038/mp.2016.71.