Gene Expression Regulation; Innate Immunity; Nucleic Acid Amplification Techniques; Nucleic Acids
Nucleic acids are versatile messenger molecules. The most prominent way of encoding information is their base sequence, that is translated by the ribosome machinery to produce proteins. Additionally, a great variety of nucleic acid modifications at the bases or internucleotide linkages as well as the nucleic acid structure and conformation can encode different information that is read out by a large set of nucleic acid sensors and processing enzymes. Within collaborative interdisciplinary research projects, I aim to harness this great potential of nucleic acids to develop new drug designs and diagnostic tools.
- Within the young independent researcher group bioSTAR, we aim to develop programmable chemical probes that are capable of sensig specific RNA sequences followed by a bioorthogonal reaction. As a first application we want to use them to target bacterial RNA sequences and test their potential as novel antibiotic drugs.
- In a second project with TU Wien and Massachusetts General Hospital we aim for new strategies that allow to track labeled biomolecules across physiologic space and time. We are working on a set of tools that can convert compact, durable chemical tags into oligonucleotide probes on demand, enabeling ultrasensitive molecular detection and seamless integration with sequencing/amplification-based biotechnologies.
- Click-activatable circular oligonucleotides for bioorthogonal translation (2021)
Source of Funding: WWTF (Vienna Science and Technology Fund), Life Sciences - Chemical Biology
- bioSTAR (2019)
Source of Funding: FWF (Austrian Science Fund), Young Independent Researcher Group
- Kuba, W. et al. (2022) ‘Oxidative Desymmetrization Enables the Concise Synthesis of a trans‐Cyclooctene Linker for Bioorthogonal Bond Cleavage’, Chemistry – A European Journal, 29(3). Available at: http://dx.doi.org/10.1002/chem.202203069.
- Goldeck, M. et al. (2022) ‘How RNA editing keeps an I on physiology’, American Journal of Physiology-Cell Physiology, 323(5), pp. C1496–C1511. Available at: http://dx.doi.org/10.1152/ajpcell.00191.2022.
- Engel, C. et al. (2017) ‘RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation’, Cancer Immunology Research, 5(6), pp. 455–467. Available at: http://dx.doi.org/10.1158/2326-6066.cir-16-0129-t.
- Goldeck, M. et al. (2014) ‘Efficient Solid-Phase Synthesis of pppRNA by Using Product-Specific Labeling’, Angewandte Chemie International Edition, 53(18), pp. 4694–4698. Available at: http://dx.doi.org/10.1002/anie.201400672.
- Ablasser, A. et al. (2013) ‘cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING’, Nature, 498(7454), pp. 380–384. Available at: http://dx.doi.org/10.1038/nature12306.