Acute Kidney Injury; Creatinine; Cytokines; Extracorporeal Circulation; Inflammation; Mortality; Patient Outcome Assessment; Perioperative Care; Preoperative Period
Organ protection, Inflammation and outcome in cardiac surgery patients
We are performing cohort studies to identify valuable predictors, models and risk indicators for several organs to facilitate possible protection and identify early dysfunctions. In this context, research about risk and prevention of acute kidney injury (AKI) in cardiac surgical patients remains the most important topic.
We are also performing prospective studies to identify the impact of inflammation due to extracorporal circulation on postoperative systemic inflammatory response syndrome and organ failure.
Techniques, methods & infrastructure
- Survival analyses and risk factor identification in collaboration with the Centre for Medical Statistics, Informatics and Intelligent Systems
- Prospective, observational cohort studies
- Analysis of inflammation markers and cytokines in cooperation with the Core Facility Flow Cytometry
- Biomarker analysis and ELISA tests
- Bernardi, M.H. et al., 2020. Urinary neprilysin for early detection of acute kidney injury after cardiac surgery. European Journal of Anaesthesiology, 38(1), pp.13–21. Available at: http://dx.doi.org/10.1097/EJA.0000000000001321.
- Bernardi, M.H. et al., 2020. Very early changes in serum creatinine are associated with 30-day mortality after cardiac surgery. European Journal of Anaesthesiology, 37(10), pp.898–907. Available at: http://dx.doi.org/10.1097/EJA.0000000000001214.
- Bernardi, M.H. et al., 2014. Impact of preoperative serum creatinine on short- and long-term mortality after cardiac surgery: a cohort study. British Journal of Anaesthesia, 114(1), pp.53-62. Available at: http://dx.doi.org/10.1093/bja/aeu316.
- Bernardi, M.H. et al., 2016. Serum Creatinine Back-Estimation in Cardiac Surgery Patients: Misclassification of AKI Using Existing Formulae and a Data-Driven Model. Clinical Journal of the American Society of Nephrology, 11(3), pp.395–404. Available at: http://dx.doi.org/10.2215/CJN.03560315.
- Bernardi, M.H. et al., 2016. Effect of hemoadsorption during cardiopulmonary bypass surgery – a blinded, randomized, controlled pilot study using a novel adsorbent. Critical Care, 20(1). Available at: http://dx.doi.org/10.1186/s13054-016-1270-0.