Detail

Keywords

Keratinocytes; Regeneration; Wound Healing

Research interests

My main research focus is to understand the processes of keratinocyte differentiation and epidermal barrier formation as well as skin regeneration after wounding. We try to identify novel factors that are important for the establishment of a functional skin barrier and characterize the modes of action of a cell secretome with strong tissue regenerative properties.

Techniques, methods & infrastructure

transcriptomics, single cell transcriptomics, proteomics, in vitro skion models, mouse wound models

Grants

• The genetic landscape of the healthy human skin (2017)
  Source of Funding: OeAD (Agency for Education and Internationalisation), Sparkling Science
  Principal Investigator

Selected publications

1. Gschwandtner, M. et al., 2014. Fetal Human Keratinocytes Produce Large Amounts of Antimicrobial Peptides: Involvement of Histone-Methylation Processes. Journal of Investigative Dermatology, 134(8), pp.2192-2201. Available at: http://dx.doi.org/10.1038/jid.2014.165.
2. Mildner, M. et al., 2013. Secretome of Peripheral Blood Mononuclear Cells Enhances Wound Healing J. M. Brandner, ed. PLoS ONE, 8(3), p.e60103. Available at: http://dx.doi.org/10.1371/journal.pone.0060103.
3. Mildner, M. et al., 2010. Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract. Mucosal Immunology, 3(6), pp.602-609. Available at: http://dx.doi.org/10.1038/mi.2010.37.
4. Mildner, M. et al., 2010. Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model. Journal of Investigative Dermatology, 130(9), pp.2286-2294. Available at: http://dx.doi.org/10.1038/jid.2010.115.
5. Mildner, M. et al., 2006. Gene silencing in a human organotypic skin model. Biochemical and Biophysical Research Communications, 348(1), pp.76-82. Available at: http://dx.doi.org/10.1016/j.bbrc.2006.07.035.