Adipose Tissue, Brown; Energy Metabolism; Positron-Emission Tomography
The main focus of my research is brown adipose tissue and energy metabolism with emphasis on brown adipose tissue imaging using 18F-FDG to better understand the physiology of human brown adipose tissue and its relevance for metabolic disease. Previous work included identification of novel molecular pathways related to energy metabolism with particular emphasis on brown fat, “browning of white fat”, and thermogenesis.
Techniques, methods & infrastructure
- clinical trials
- 18F-FDG PET/CT and PET/MRI scanning
- indirect calorimetry
- cell culture
- Seahorse analyses
- Kulterer, O.C. et al. (2022) ‘Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact’, Frontiers in Endocrinology, 13. Available at: http://dx.doi.org/10.3389/fendo.2022.858417.
- Kulterer, O.C. et al. (2020) ‘The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans’, The Journal of Clinical Endocrinology & Metabolism, 105(7), pp. 2203–2216. Available at: http://dx.doi.org/10.1210/clinem/dgaa183.
- Hedesan, O.C. et al. (2018) ‘Parathyroid hormone induces a browning program in human white adipocytes’, International Journal of Obesity, 43(6), pp. 1319–1324. Available at: http://dx.doi.org/10.1038/s41366-018-0266-z.
- Fenzl, A. et al. (2020) ‘Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis’, Molecular Metabolism, 42, p. 101088. Available at: http://dx.doi.org/10.1016/j.molmet.2020.101088.
- Kulterer, O.C. et al. (2020) ‘A Microdosing Study with 99mTc-PHC-102 for the SPECT/CT Imaging of Primary and Metastatic Lesions in Renal Cell Carcinoma Patients’, Journal of Nuclear Medicine, 62(3), pp. 360–365. Available at: http://dx.doi.org/10.2967/jnumed.120.245530.