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Shweta Tikoo
Dr. Shweta Tikoo, Ph.DPrincipal Investigator


Breast Cancer; Drug Discovery; Hematopoiesis; Hematopoietic System; High-Throughput Screening Assays; Imaging, Three-Dimensional; Inflammation; Innate Immunity; Macrophages; Melanoma; Melanoma, Amelanotic; Monocyte-Macrophage Precursor Cells; Myeloid Cells; Myeloid Progenitor Cells

Research interests

Current Research Projects

  1.    Deciphering the ontogeny of macrophage development in health and disease
  2.    Elucidating the role of perivascular macrophages in breast cancer development and metastasis
  3.    Imaging dynamics of immune cells in the melanoma tumour microenvironment
  4.    Understanding the role of perivascular macrophages in contact hypersensitivity
  5.    Targeting protein trafficking pathways in melanoma
  6.    Understanding the role of perivascular macrophages in leukocyte trafficking during sterile inflammation

Higher Degree Supervision

PhD Supervision (As Primary Supervisor)

  1.    Dr. Dajiang Guo (PhD Awarded 2020, The University of Sydney)
  2.    Dr. Kathy On (PhD Awarded 2021, The University of Sydney)
  3.    Dr. Nursafwana Syazwani (PhD Awarded 2021, The University of Sydney)

Undergraduate Supervision

  1.    Ms. Caitlin Ung (1st Class Honours, 2016, The University of Sydney)
  2.    Ms. Emilie Wong (1st Class Honours, 2021, The University of Sydney)

MD Research Supervision

  1.    Ms. Shemani V Jagoda (2021, Sydney Medical School, The University of Sydney)

Research Assistant Supervision

  1.    Ms Lisa Shaw, 2014-2015 (Centenary Institute of Cancer Medicine and Cell Biology)
  2.    Mr Brendon Martinez, 2016-2018 (Centenary Institute of Cancer Medicine and Cell Biology)

Selected publications

  1. Tikoo S*, Jain R*,#, Martinez B, Rizzetto S, Shaw L, Mitchell AJ, Pacheco EMT, Luciani F, Jung S, Fraser ST, and Weninger W#. A yolk sac independent erythro-myeloid progenitor resides in the bone marrow and generates macrophages during inflammation in the adult. bioRxiv *Equal first authors, # Co-corresponding authors
  2. Tikoo S*, #,†, Jain R*, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy, P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, and Weninger W#. Amelanotic B16-F10 melanoma compatible with advanced 3D-imaging modalities. The Journal of Investigative Dermatology, 141(8): 2090-2094, *Equal first authors, #Co-senior authors, †Corresponding author
  3. Jain R*,#, Tikoo S*, On K, Martinez B, and Weninger W#. Visualising immune response in murine breast tumours by intravital multiphoton microscopy. STAR Protocols 2, 100722, *Equal first authors, #Co-corresponding authors
  4. Tikoo, S*, Barki, N*, Jain, R, et al. Imaging of Mast Cells. Immunological reviews, 282(1):58-72, *Equal first authors #Co-corresponding authors
  5. Tikoo S, Madhavan V, et al. Ubiquitin-dependent recruitment of the Bloom Syndrome helicase in response to replication stress is required to suppress homologous recombination. EMBO Journal, 32(12): 1778-92