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Detail

Sonja Sucic
Assoc. Prof. Sonja Sucic, PhD

Center for Physiology and Pharmacology (Institute of Pharmacology)
Position: Associate Professor

ORCID: 0000-0001-5136-8022
T +43 1 40160 31376
sonja.sucic@meduniwien.ac.at

Further Information

Keywords

Folding and targeting of neurotransmitter transporters and GPCRs; Intellectual Disability; Molecular Mechanisms of Pharmacological Action; Mutation, Missense; Neuropharmacology; Neuropsychopharmacology; Neurotransmitter Transporters; Neurotransmitter Uptake Inhibitors; Parkinsonian Disorders

Research interests

The main focus of research in our lab are neurotransmitter transporters, in particular the solute carrier 6 (SLC6) family: the molecular mechanisms of protein folding, ER export and trafficking and pharmacological rescue of dysfunctional/misfolded SLC6 transporter variants linked to various transporter pathologies (e.g. infantile parkinsonism/dystonia, intellectual disability and epilepsy). Other ongoing projects in the lab deal with the molecular structure-function relationships of SLC6 transporters and their interactions with antidepressant and psychostimulant drugs.

https://www.mdpi.com/journal/cells/special_issues/neuro_trans

Techniques, methods & infrastructure

Pharmacological assays (uptake, binding and efflux), molecular biology and biochemistry (site-directed mutagenesis, DNA/RNA purification, cell surface biotinylation, immunoblotting, immunocytochemistry), cell culture (primary neuronal cultures, established cell lines, transient and stable transfections, siRNA-induced knock-down…), microscopy (confocal laser scanning microscopy and förster resonance energy transfer (FRET), collaborative projects investigating transporters in flies (Drosophila melanogaster).  

Grants

Selected publications

  1. Bhat, S. et al., 2021. Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits. Pharmacology & Therapeutics, 222, p.107785. Available at: http://dx.doi.org/10.1016/j.pharmthera.2020.107785.
  2. Farr, C.V. et al., 2020. The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome. Frontiers in Synaptic Neuroscience, 12. Available at: http://dx.doi.org/10.3389/fnsyn.2020.588954.
  3. El-Kasaby, A. et al., 2019. Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome. Neuropharmacology, 161, p.107572. Available at: http://dx.doi.org/10.1016/j.neuropharm.2019.03.015.
  4. Asjad, H.M.M. et al., 2017. Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism. Journal of Biological Chemistry, 292(47), pp.19250–19265. Available at: http://dx.doi.org/10.1074/jbc.M117.797092.
  5. Kern, C. et al., 2017. The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter. Journal of Biological Chemistry, 292(9), pp.3603–3613. Available at: http://dx.doi.org/10.1074/jbc.m116.771360.