Center for Medical Biochemistry (Division of Molecular Genetics)
Position: Associate Professor
ORCID: 0000-0002-3721-7225
T +43 1 4277-61777
ulrich.salzer@meduniwien.ac.at
Keywords
Ascorbic Acid; Blood Coagulation; Blood Physiological Processes; Erythrocyte Aging; Erythrocyte Membrane; Erythrocyte Transfusion; Pantothenate Kinase-Associated Neurodegeneration
Research interests
Erythrocytes are by far the most abundant cells of the human body. Having long been regarded only in the context of oxygen transport, the notion of the importance of these cells is steadily growing. Erythrocytes are crucially involved in many physiologic processes, alterations are observed in a large variety of diseases and blood transfusions is among the most common clinical interventions. I am specifically interested in erythrocyte membrane processes, like vitamin C transport or exovesiculation, in the physiologic function of erythrocytes in blood clotting and in molecular aberrations of erythrocytes associated with monogenetic neurodegenerative diseases (PKAN, NBIA, ChAc).
Selected publications
- Eigenschink, M. et al., 2021. Redox Properties of Human Erythrocytes Are Adapted for Vitamin C Recycling. Frontiers in Physiology, 12. Available at: http://dx.doi.org/10.3389/fphys.2021.767439.
- Werning, M. et al., 2020. PKAN neurodegeneration and residual PANK2 activities in patient erythrocytes. Annals of Clinical and Translational Neurology, 7(8), pp.1340–1351. Available at: http://dx.doi.org/10.1002/acn3.51127.
- Öhlinger, T. et al., 2020. Lysophosphatidic acid-induced pro-thrombotic phosphatidylserine exposure and ionophore-induced microvesiculation is mediated by the scramblase TMEM16F in erythrocytes. Blood Cells, Molecules, and Diseases, 83, p.102426. Available at: http://dx.doi.org/10.1016/j.bcmd.2020.102426.
- Oberwagner, W. et al., 2017. Drug-induced endovesiculation of erythrocytes is modulated by the dynamics in the cytoskeleton/membrane interaction. Blood Cells, Molecules, and Diseases, 64, pp.15–22. Available at: http://dx.doi.org/10.1016/j.bcmd.2017.03.004.
- Salzer, U., Kostan, J. & Djinović-Carugo, K., 2017. Deciphering the BAR code of membrane modulators. Cellular and Molecular Life Sciences, 74(13), pp.2413–2438. Available at: http://dx.doi.org/10.1007/s00018-017-2478-0.