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Wilfried Ellmeier
Univ.Prof.Mag.Dr. Wilfried EllmeierHead, Institute of Immunology

Center for Pathophysiology, Infectiology and Immunology (Institute of Immunology)
Position: Professor

ORCID: 0000-0001-8192-8481
T +43 1 40160 33293

Further Information


Autoimmunity; Chromatin; Gene Regulatory Networks; Histone Deacetylases; Inflammation; T Cells; T-Lymphocyte Subsets

Research interests

Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:

• Histone deacetylase function in T cell-mediated immunity

• Transcriptional control of T cell development and function

• Regulation of T cell lineage identity and integrity

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Techniques, methods & infrastructure

We are embedded in a strong collaborative environment and the experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.


Selected publications

  1. Sakaguchi, S. et al., 2010. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nature Immunology, 11(5), pp.442–448. Available at:
  2. Boucheron, N. et al., 2014. CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nature Immunology, 15(5), pp.439–448. Available at:
  3. Göschl, L. et al., 2018. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 86, pp.51–61. Available at:
  4. Ellmeier, W. & Seiser, C., 2018. Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18(10), pp.617–634. Available at:
  5. Hamminger, P. et al., 2021. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of Autoimmunity, 119, p.102610. Available at: