Detail

Keywords

Autoimmunity; Chromatin; Gene Regulatory Networks; Histone Deacetylases; Inflammation; T Cells; T-Lymphocyte Subsets

Research interests

Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:

• Histone deacetylase function in T cell-mediated immunity

• Transcriptional control of T cell development and function

• Regulation of T cell lineage identity and integrity

For more information please visit: www.meduniwien.ac.at/immunobiology

Techniques, methods & infrastructure

We are embedded in a strong collaborative environment and the experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.

Grants

• NCOR1-mediated control of intestinal CD4+ T cell immunity (2021)
  Source of Funding: FWF (Austrian Science Fund), Stand-alone
  Principal Investigator
• MAZR isoform-specific functions in T cells and beyond (2021)
  Source of Funding: FWF (Austrian Science Fund), Stand-alone project
  Principal Investigator
• European Network Linking Informatics and Genomics of Helper T cells in Tissues (2020)
  Source of Funding: EU, Innovative Training Network (ITN)
  Principal Investigator
• HDACs as regulators of T cell-mediated immunity in health and disease (2019)
  Source of Funding: FWF (Austrian Science Fund), Special Research Program (SFB)
  Coordinator of the collaborative project

Selected publications

1. Sakaguchi, S. et al., 2010. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nature Immunology, 11(5), pp.442–448. Available at: http://dx.doi.org/10.1038/ni.1860.
2. Boucheron, N. et al., 2014. CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nature Immunology, 15(5), pp.439–448. Available at: http://dx.doi.org/10.1038/ni.2864.
3. Göschl, L. et al., 2018. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 86, pp.51–61. Available at: http://dx.doi.org/10.1016/j.jaut.2017.09.008.
4. Ellmeier, W. & Seiser, C., 2018. Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18(10), pp.617–634. Available at: http://dx.doi.org/10.1038/s41577-018-0037-z.
5. Hamminger, P. et al., 2021. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of Autoimmunity, 119, p.102610. Available at: http://dx.doi.org/10.1016/j.jaut.2021.102610.