
Center for Pathophysiology, Infectiology and Immunology (Institute of Immunology)
Position: Professor
ORCID: 0000-0001-8192-8481
T +43 1 40160 33293
wilfried.ellmeier@meduniwien.ac.at
Keywords
Autoimmunity; Chromatin; Gene Regulatory Networks; Histone Deacetylases; Inflammation; T Cells; T-Lymphocyte Subsets
Research interests
Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:
• Histone deacetylase function in T cell-mediated immunity
• Transcriptional control of T cell development and function
• Regulation of T cell lineage identity and integrity
For more information please visit: www.meduniwien.ac.at/immunobiology
Techniques, methods & infrastructure
We are embedded in a strong collaborative environment and the experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.
Grants
- NCOR1-mediated control of intestinal CD4+ T cell immunity (2021)
Source of Funding: FWF (Austrian Science Fund), Stand-alone
Principal Investigator - MAZR isoform-specific functions in T cells and beyond (2021)
Source of Funding: FWF (Austrian Science Fund), Stand-alone project
Principal Investigator - European Network Linking Informatics and Genomics of Helper T cells in Tissues (2020)
Source of Funding: EU, Innovative Training Network (ITN)
Principal Investigator - HDACs as regulators of T cell-mediated immunity in health and disease (2019)
Source of Funding: FWF (Austrian Science Fund), Special Research Program (SFB)
Coordinator of the collaborative project
Selected publications
- Boucheron, N. et al. (2014) ‘CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2’, Nature Immunology, 15(5), pp. 439–448. Available at: https://doi.org/10.1038/ni.2864.
- Ellmeier, W. and Seiser, C. (2018) ‘Histone deacetylase function in CD4+ T cells’, Nature Reviews Immunology, 18(10), pp. 617–634. Available at: https://doi.org/10.1038/s41577-018-0037-z.
- Hamminger, P. et al. (2021) ‘Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases’, Journal of Autoimmunity, 119, p. 102610. Available at: https://doi.org/10.1016/j.jaut.2021.102610.
- Preglej, T. and Ellmeier, W. (2022) ‘CD4+ Cytotoxic T cells – Phenotype, Function and Transcriptional Networks Controlling Their Differentiation Pathways’, Immunology Letters, 247, pp. 27–42. Available at: https://doi.org/10.1016/j.imlet.2022.05.001.
- Stolz, V. et al. (2024) ‘Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function’, eLife, 13. Available at: https://doi.org/10.7554/elife.78738.