Krššák & Just

Universitätsklinik für Innere Medizin III
Klinische Abteilung für Endokrinologie und Stoffwechsel

Lorenz Pfleger
Joseph Taylor
Kanji Cho
Visolakhon Ismailova
Hana Skuciova

Body >> Ganzkörper und Abdomen

Fett-/Muskel Verteilung vom Kopf bis zum Fuß, Subcutanes und Viscerales Fettgewebe - ¹H MRI

Akkumulation von Fett in der Leber (HCL,PDFF) und Pancreas - ¹H MRS/I
Zusammensetzung der Gallensäuren - ¹H und ³¹P MRS
 

Body >> Herz

Funktionelle und strukturelle Bildgebung vom Herz - CineMRI
Akummulation von Fett im Septum (MYCL) - ¹H MRS

Body >> Muskel

Morphologische Bildgebung vom Skelettmuskel
Akummulation von Fett im Muskel (IMCL,IMAT) - ¹H MRS/I

Neuro >> Strukturelle Bildgebung

Hirnstrukturen und funktionellen Verbindungen im Alter und der Einfluss von Life-Style Interventions

Stoffwechsel >> Leber

Akummulation und Zusamensetzung von Fett in der Leber (HCL, Unsaturation) - ¹H MRS/I
Zucker-, Glykogen- und Fettstoffwechsel der Leber - ²H MRSI / DMI ; ¹³C MRS
Energiestoffwechsel der Leber - ³¹P MRS
 

Stoffwechsel >> Muskel

Intramyocellulären Lipiden (IMCL), Acetyl-Carnitine, Carnosine und Taurin - ¹H MRS
Oxidativer Mitochondrialer Stoffwechsel - dynamische ³¹P MRS & ¹H MRS
Alterungs- und Pathologie- Spezifischen Änderungen - ³¹P MRS (Glycerophosphocholine, NADH)
Glykogenspeicherung -  ¹³C MRS

Stoffwechsel >> X-Kern MRS & I (²H, ¹³C, ²³Na, ³¹P)

• Mechanism-based Reversibility Evaluation and Stratified Endophenotyping of Treatment-response in ME/CFS – ME-RESET WWTF, ME/CFS26-004, 2027-2029, Cooperation with Prof. L. Haider, Neuroradiology
• Effects of metyrapone treatment on cardio-metabolic risk and chronobiology in patients with mild autonomous cortisol secretion. WWTF, LS25-009, 2026-2030
• The role of the skeletal muscle and myocardial metabolism in ME/CFS: in vivo MRS study WWTF, ME/CFS24-007, 2025-2026
• Metabolic Control of Aging and Disease; FWF Cluster of Excellence “PromMetAGE Cohort”, FWF CoE-014, 2024-2028
• Preventing Aging by Exercise. Non-invasive MR based detection of metabolic and structural adaptation to exercise in the muscle and brain. FWF-KLI-1122B, 2023-27
• Non-invasive markers of muscular metabolic flexibility. FWF-KLI-904B, 2021-25
• Tracking Nutrient Metabolism and Cellular Partitioning by Multimodal Molecular Imaging. WWTF, LS19-46, 2020-2024
• Christian Doppler Laboratory for Clinical Molecular Imaging – MOLIMA - CD10277101, 2018 – 2021 – PI – Prof. S. Trattnig
• Myokardiale Lipid- und Glykogenspeicherung bei Patienten mit Prädiabetes- und Type 2 Diabetes. ÖNB 2013; Nr. 15363
• Unravelling the pathogenetic mechanisms of fructose consumption as multiple hit in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) - WWTF, LS12-008, PI - Prof. Trauner, Prof. Krebs
• Effects of impaired glucose homeostasis on cardiac function and lipid metabolism. Magnetic Resonance Spectroscopy and Imaging Study – ÖNB 2009; Nr. 13249

• Dr. B. Ukropcová, Dr. J. Ukropec – Biomedical Research Center, Inst. Exp. Endocrinology, Slov Acad Sciences, Bratislava, SVK
• Dr. R. Klepochova - Institute of Measurement Science, Slov Acad Sciences, Bratislava, SVK
• Prof. V. Schrauwen-Hinderling, Prof. M. Roden - German Diabetes Center, Düsseldorf, Germany
• Prof. D. König, Prof. K.H. Wagner – Dpt. of Nutrition, University of Vienna
• Prof. L. Valkovic, Dr. J. McGing – University of Oxford
• Dr. M. Hájek, Dr. M. Dezortová, Prof. Jirák, Dr. D. Pajuelo, Dr. P. Sedivy - Institute for Clinical and Experimental Medicine, Prague, CZ
• Dr. J. Starcukova, Dr. R. Korinek, Dr. Z. Starcuk – Institute of Scientific Instruments, CzAS, Brno, CZ
• Dr. P. Hnilicova, Jesenius Faculty of Medicine, Comenius University, Martin, SVK

• L. Pfleger, V. Bader, F. Niess, A. Tosin, C. Baumgartner, P. Wolf, A. Duguid, B. Strasser, T. Scherer, W. Bogner, M. Krššák. Deuterium Metabolic Imaging-based Methods for Assessment of the Hepatocellular Lipid Content. Accepted for NMR Biomed in November 2026 DOI:10.1002/nbm.70442
• B. Kollár, A. Penesová, R. Klepochová, P. Šiarnik, M. Vlček, P. Krumpolec, L. Mosná, R. Imrich, P. Turčáni, Ž. Rádiková, M. Krššák. Skeletal muscle mitochondrial impairment in patients with newly diagnosed multiple sclerosis revealed by ¹H/³¹P magnetic resonance spectroscopy. Sci Rep. 2026 Jun 11;16(1):26621. doi: 10.1038/s41598-026-54705-8.
• D. Pajuelo, R. Klepochová, P. Šedivý, M, Dezortová, I. Just, P. Kordač, M. Hájek, B. Ukropcová, J. Ukropec, P. Szomolanyi, P. Taimr, L. Horváth, M. Dubský, D. Sojáková, M. Krššák. Adaptation of Quality Control Pipeline for Skeletal Muscle 31P MR Spectroscopy at 3T and 7T. Z Med Phys. 2026 Jun 18:S0939-3889(26)00059-0. doi: 10.1016/j.zemedi.2026.05.004. Online ahead of print.
• H.M. Niziolek; I. Just; A. Tosin; C. Baumgartner; O. Koldyka, P. Fellinger; H. Beiglböck; L. Bellach; O. Domenig, M. Zeyda, H. Habisch, T. Madl, A. Luger; G. Vila; S. Trattnig, A. Kautzky-Willer; T. Scherer; M. Leutner; M. Krebs; M. Krššák; P. Wolf. "Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis” J Clin Endocrinol Metab. 2026 Jun 11:dgag228. doi: 10.1210/clinem/dgag228. Online ahead of print. 
• A. Amiri, M. Schön, R. Klepochová, V. Litváková, R. Pechancová, K. Rerková, K. Marček Malenovská, M. Prievalský, L. Slobodová, V. Oliva, T. Pluháček, M. Sedliak, M. Mego, M. Krššák, M. Chovanec, B. Ukropcová, J. Ukropec. The effects of regular exercise on cognitive and cardiometabolic health in testicular cancer patients and survivors subjected to platinum-based chemotherapy. Andrology 2025 13:2181–2194. First published: 09 January 2025 https://doi.org/10.1111/andr.13829
• R. Klepochová, F. Niess, M. Metz, B. Ukropcová, J. Ukropec, S. Trattnig, A. Kautzky-Willer, M. Krššák, M. Meyerspeer. ¹H and ³¹P MRS interleaved with high time resolution reveals closely matching creatine CH₂ and PCr dynamics during exercise. NMR Biomed. 2025 Oct;38(10):e70132. doi: 10.1002/nbm.70132.
• M. Beghini,  M. Metz, C. Baumgartner, P. Wolf, M. Bastian, M. Hackl, S. Baumgartner-Parzer, R. Marculescu, M. Krebs, J. Harreiter, J. von Schnurbein, S. Brandt-Huenemann, K. Miehle, G. Ceccarini, S. Magno, C. Pelosini, C. Tran, A. Gambineri, C. Cecchetti, M. Krššák, L. Pfleger, M. Trauner, A. Kautzky-Willer, M. Stumvoll, M. Wabitsch, F. Santini, I. Turan, B. Akinci, H. Stangl, C. Fürnsinn, T. Scherer.  Leptin increases hepatic triglyceride secretion in patients with lipodystrophy, Metabolism. 2025 Aug;169:156261. doi: 10.1016/j.metabol.2025.156261. Epub 2025 Apr 7.
• D. Sitarcikova, S. Poetter-Lang, S. Ba-Ssalamah, N. Bastati, U. Attenberger, S. Trattnig, A. Ba-Ssalamah, M. Krššák. Diagnostic Accuracy of Texture Analysis Applied to T1- and T2-Relaxation Maps for Liver Fibrosis classification via machine-learning algorithms with Liver Histology as Reference Standard. Eur J Radiol. 2025 Feb;183:111887. doi: 10.1016/j.ejrad.2024.111887. Epub 2024 Dec 20.
• V. Ehret, U. Ustsinau, J. Friske, T. Scherer, C. Fürnsinn, J. Starcukova, T. Helbich, C. Philippe, M. Krššák.  Deuterium metabolic imaging enables the tracing of substrate fluxes through the tricarboxylic acid cycle in the liver. NMR in Biomedicine, 2025; 38:e5309, https://doi.org/10.1002/nbm.5309
• D. Sluková, C. Deischinger, I. Just, U. Kaufmann, S. Trattnig, M. Krššák, L. Kosi-Trebotic, J. Harreiter, A. Kautzky-Willer. The effects of gender-affirming hormone therapy on myocardial, hepatic, pancreatic lipid content, body fat distribution and other cardiometabolic risk factors: A magnetic resonance-based study in transgender individuals. J Clin Transl Endocrinol. 2024 Dec 6;39:100379. doi: 10.1016/j.jcte.2024.100379. eCollection 2025 Mar.
• V. Ehret, U. Ustsinau, J. Friske, T. Scherer, C. Fürnsinn, T. Helbich, C. Philippe, M. Krššák.   Evaluation of Hepatic Glucose and Palmitic Acid Metabolism in Rodents on High-Fat Diet Using Deuterium Metabolic Imaging. J Magn Reson Imaging 2025,  61 (2): 958-967, doi: 10.1002/jmri.29437.
• Harreiter J, Just I, Weber M, Klepochová R, Bastian M , Winhofer Y, Leutner M, Wolf P, Scherer T, Kosi-Trebotic L, Deischinger C, Chmelík M, Krebs M, Trattnig S, Krššák M, Kautzky-Willer A, Sex differences in hepatic and cardiac lipid accumulation and cardiac function across a cohort with wide range of glycemia: A secondary, cross-sectional analysis. Obesity 2024, 32(12) 2299-2309. http://doi.org/10.1002/oby.24153 online Nov 19 2024
• P. Hnilicová, M. Grendar, M. Turcanova Koprusakova. A. Trancikova Kralova, M. Krššák, I. Just, N. Misovicova, M. Hikkelova, J. Grossmann, P. Spalek, I. Meciarova, E. Kurca, N. Zilka, K. Zelenak, W. Bogner, M. Kolisek. Brain of Miyoshi Myopathy/ Dysferlinopathy Patients Presents with Structural and Metabolic Anomalies. Sci Rep. 2024 Aug 20;14(1):19267. doi: 10.1038/s41598-024-69966-4.
• D.Cikes, M. Leutner, S.J.F. Cronin, M. Novatchkova, L. Pfleger, R. Klepochová, E. Rullman, B. Lair, M. Lac, C. Bergoglio, N. Viguerie, G. Dürnberger, E. Roitinger, E. Rullman, T. Gustafsson, A. Hagelkruys, G. Tavernier, V. Bourlier, C. Knauf, M. Krebs, A. Kautzky-Willer, C. Moro, M. Krššák, M. Orthofer, J. M. Penninger. Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nat Aging. 2024 Jan;4(1):80-94. doi: 10.1038/s43587-023-00551-6. Epub 2024 Jan 18.
• R. Klepochová, F. Niess, M. Meyerspeer, D. Slukova, I. Just, S. Trattnig, J. Ukropec, B. Ukropcová, A. Kautzky-Willer, M. Leutner, M. Krššák, Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved 1H/31P MRS 7T study. Sci Rep. 2024 Feb 8;14(1):3254. doi: 10.1038/s41598-024-53221-x.
• A. M. Moitzi, M. Krššák, R Klepochová, C. Triska, R. Csapo and D. König. Effects of a 10-Week Exercise and Nutritional Intervention with Variable Dietary Carbohydrates and Glycaemic Indices on Substrate Metabolism, Glycogen Storage, and Endurance Performance in Men: A Randomized Controlled Trial. Sports Med Open. 2024 Apr 10;10(1):36. doi: 10.1186/s40798-024-00705-9.