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Detail

Alfred Gugerell
Mag. Dr. Alfred Gugerell

Department of Surgery (Division of Thoracic Surgery)
Position: Research Associate (Postdoc)

ORCID: 0000-0002-5178-9967
T +43 1 40400 69790
alfred.gugerell@meduniwien.ac.at

Keywords

Cardiology; Clinical Trial, Phase II; Culture Media, Conditioned; Diabetic Foot; Fibrin; Imaging, Three-Dimensional; Quality Control; Regeneration; Regenerative Medicine; Tissue Engineering; Wound Healing

Research interests

As a human biologist (anthropology) his scientific background lies in the cell biology and molecular biology. Currently, he is responsible for clinical development and acts as internal project manager of the clinical phase II study MARSYAS II. Prior to that, he worked in the field of cellular transformation in acute myocardial infarction in porcine in vivo models and could gain experiences in soft tissue-engineering and wound-healing research in Plastic and Reconstructive Surgery at the Medical University of Vienna. His PhD thesis discussed the application of fibrin sealant in wound healing (Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Baxter Bioscience).

Techniques, methods & infrastructure

Primary cell culture, histology, imaging,flow cytometry, RNA, proteins

Selected publications

  1. Gugerell, A. et al., 2019. Viral safety of APOSEC™: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine. Blood Transfusion, 2019 Feb 21
  2. Spannbauer, A. et al., 2019. Large Animal Models of Heart Failure With Reduced Ejection Fraction (HFrEF). Frontiers in Cardiovascular Medicine, 6. Available at: http://dx.doi.org/10.3389/fcvm.2019.00117.
  3. Gugerell, A. et al., 2014. Thrombin as important factor for cutaneous wound healing: Comparison of fibrin biomatrices in vitro and in a rat excisional wound healing model. Wound Repair Regen, 22(6), pp.740-748. Available at: http://dx.doi.org/10.1111/wrr.12234.
  4. Gugerell, A. et al., 2014. Botulinum toxin A and lidocaine have an impact on adipose-derived stem cells, fibroblasts, and mature adipocytes in vitro. Journal of Plastic, Reconstructive & Aesthetic Surgery, 67(9), pp.1276-1281. Available at: http://dx.doi.org/10.1016/j.bjps.2014.05.029.
  5. Gugerell, A. et al., 2012. High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes. Journal of Biomedical Materials Research Part A, 100A(5), pp.1239-1247. Available at: http://dx.doi.org/10.1002/jbm.a.34007.