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Detail

Eva-Maria Klebermass
Mag. pharm. Eva-Maria Klebermass

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: PHD Student

T +43 1 40400 15570
eva-maria.klebermass@meduniwien.ac.at

Keywords

Carbohydrate Metabolism; Diagnostic Imaging; Metabolism; Oncology; Positron-Emission Tomography; Radioactive Tracers

Research interests

My research interest lies on the visualisation and characterisation of carbohydrate pathways in health and disease with the help of PET-tracers. At the moment I focus on oncological applications and the gold standard of PET imaging, 2-[18F]FDG. The pentose phosphate pathway is of main interest, as is the development of new imaging probes targeting different carbohydrate pathways. 

Techniques, methods & infrastructure

  • 2D and 3D cell culture
  • analytical HPLC
  • real-time measurement of protein interactions 
  • drug accumulation assays
  • western blots, PCR, immunohistochemistry

Selected publications

  1. Bauer, M. et al., 2017. Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography. Clinical Pharmacology & Therapeutics, 104(1), pp.139-147. Available at: http://dx.doi.org/10.1002/cpt.888.
  2. Vraka, C. et al., 2018. A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter. Nuclear Medicine and Biology, 60, pp.29-36. Available at: http://dx.doi.org/10.1016/j.nucmedbio.2018.02.002.
  3. Vraka, C. et al., 2018. Expanding LogP: Present possibilities. Nuclear Medicine and Biology, 58, pp.20-32. Available at: http://dx.doi.org/10.1016/j.nucmedbio.2017.11.007.
  4. Sundar, L.K. et al., 2018. Towards quantitative [18F]FDG-PET/MRI of the brain: Automated MR-driven calculation of an image-derived input function for the non-invasive determination of cerebral glucose metabolic rates. Journal of Cerebral Blood Flow & Metabolism, p.0271678X1877682. Available at: http://dx.doi.org/10.1177/0271678X18776820.
  5. Gryglewski, G. et al., 2017. Simple and rapid quantification of serotonin transporter binding using [ 11 C]DASB bolus plus constant infusion. NeuroImage, 149, pp.23-32. Available at: http://dx.doi.org/10.1016/j.neuroimage.2017.01.050.