Department of Anaesthesia, Intensive Care Medicine and Pain Medicine (Division of General Anaesthesia and Intensive Care Medicine)
Position: Consultant
ORCID: 0000000269509361
T +43 1 4040041020
katharina.krenn@meduniwien.ac.at
Keywords
Acute Lung Injury; Clinical Trial; Intensive Care; Renin-Angiotensin System
Research group(s)
- Lung research group
Members:
Research interests
My research focuses are clinical trials in critical care medicine, acute lung injury/acute respiratory distress syndrome and the renin-angiotensin-system in critical illness and the perioperative period. Currently, my research group is participating in the multicenter phase IIb trial on AP301/solnatide as inhalation therapy for ARDS.
Grants
- The angiotensin metabolite profile after subarachnoid hemorrhage (2021)
Source of Funding: FWF (Austrian Science Fund), KLIF
Principal Investigator
Selected publications
- Krenn, K. et al., 2017. Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial. Critical Care, 21(1). Available at: http://dx.doi.org/10.1186/s13054-017-1795-x.
- Schmid, B. et al. (2021) ‘Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial’, Trials, 22(1). Available at: https://doi.org/10.1186/s13063-021-05588-9.
- Mao, X. et al. (2022) ‘Tidal Volume–Dependent Activation of the Renin-Angiotensin System in Experimental Ventilator-Induced Lung Injury*’, Critical Care Medicine, 50(9), pp. e696–e706. Available at: https://doi.org/10.1097/ccm.0000000000005495.
- Mao, X. et al. (2023) ‘Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice’, Frontiers in Physiology, 14. Available at: https://doi.org/10.3389/fphys.2023.1109452.