Allergy and Immunology; Langerhans Cells; Mast Cells; Tissue Culture Techniques
The crosstalk between resident skin cells and immune cells plays an important role in health and disease. We showed recently that mast cells can repress the expression of differentiation-associated proteins in keratinocytes by release of the inflammatory mediator histamine. Immune cells therefore have great influence on the perturbed epidermal differentiation and skin barrier function that is observed in a majority of patients with inflammatory skin diseases - resulting in increased invasion of noxious substances (e.g. allergens and irritants) into the skin as well as fluid loss to the outside. At the moment we are working on the elucidation of the mechanism by which immune mediators, like histamine and different interleukins, influence skin development and differentiation. Moreover, we are investigating other mast cell functions relevant for inflammatory skin diseases; a study that is based on the characterization of human primary skin mast cells using microarrays and proteomics.
- The role of mast cells in skin homeostasis and inflammation (2016)
Source of Funding: FWF (Austrian Science Fund), Elise Richter
- The role of mast cells in skin barrier function (2011)
Source of Funding: FWF (Austrian Science Fund), Hertha Firnberg