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Detail

Markus  Kunze
Dr.rer.nat. Markus Kunze

Center for Brain Research (Division of Pathobiology of the Nervous System)
Position: Research Assistant

T +43 1 40160 34094
markus.kunze@meduniwien.ac.at

Keywords

Adrenoleukodystrophy; Alzheimer Disease; ATP-Binding Cassette Transporters; Evolution, Molecular; Lipid Metabolism; Peroxisomes; Protein Transport

Research interests

Intracellular Transport Processes

A variety of metabolic pathways are sequestered within peroxisomes. Thus, the participating enzymes and the metabolic substrates have to be imported into this organelle. The mechanisms mediating an efficient and specific transport of soluble and membrane proteins to peroxisomes are a major focus of interest. The transfer of small organic compounds across the peroxisomal membrane by specific transporter proteins and the metabolic interconversion of these compounds within peroxisomes are the second major focus. Both aspects are of medical importance, because a dysfunction in transport processes has been linked to human diseases such as X-linked adrenoleukodystrophy, Alzheimers disease or metabolic disorders. 

Techniques, methods & infrastructure

Immunofluorescenc Microscopy, Western Blot, Subcellular Fractionation, Density Gradient Centrifugation, Yeast Two Hybrid Assay, Mammalian Two Hybrid Assay, Immunoprecipitation, Cell Culture Techniques, PCR, qRT-PCR

Selected publications

  1. Kunze M (2020) The type-2 peroxisomal targeting signal BBA Mol Cell Res, 1867 (2): 118609
  2. Chong CS*/Kunze M* (*joint authorship) Hochreiter , Krenn , Berger , Maurer-Stroh (2019) Rare Human Missense Variants can affect the Function of Disease-Relevant Proteins by Loss and Gain of Peroxisomal Targeting Motifs Int J Mol Sci, 20 (18): 4609
  3. Kunze M (2018) Predicting Peroxisomal Targeting Signals to Elucidate the Peroxisomal Proteome of Mammals. In: del Río, Luis A. (Ed.), Subcellular Biochemistry Vol. 69: Peroxisomes and their Key Role in Cellular Signaling and Metabolism Springer Verlag, Heidelberg: 157-199
  4. Berger J, Dorninger F, Forss-Petter S, Kunze M (2016) Peroxisomes in brain development and function Biochim Biophys Acta, 863: 934-955
  5. Kunze M, Malkani N, Maurer-Stroh S, Wiesinger C, Schmid J, Berger J (2015) Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: The Co-receptor PEX5L drastically increases the Interaction Strength between the Cargo Protein and the Receptor PEX7 J Biol Chem, 290: 4928-4940