Nutrition and Dietetics; Public Health; Sports Medicine
My main research focus is to elucidate mechanism controlling trophoblast determination. Proliferation, differentiation and specific maturation of human trophoblasts is a critical requirement for a proper placenta formation/function during pregnancy and failures are associated with pregnancy disorders such as preeclampsia and intrauterine growth restriction. To date, very little is known about human trophoblast progenitor cells and key factors that would determine their differentiation route along multinucleated syncytiotrophoblasts or extravillous invasive cytotrophoblasts. The identification of such factors and pathways would improve the understanding of placenta formation and might help to elucidate the etiology of placenta-associated pregnancy disorders.
Techniques, methods & infrastructure
Primary cell culture of human trophoblasts, villous explant culture model systems and trophoblastic cell lines are used for in vitro analysis. A broad spectrum of biochemical, cell biological, and imaging techniques are used.
- Haider, S. et al., 2014. Notch Signaling Plays a Critical Role in Motility and Differentiation of Human First-Trimester Cytotrophoblasts. Endocrinology, 155(1), pp.263-274. Available at: http://dx.doi.org/10.1210/en.2013-1455.
- Bauer, S. et al., 2004. Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab. 2004 Feb;89(2):812-22.
- Haider, S. & Knöfler, M., 2009. Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium. Placenta, 30(2), pp.111-123. Available at: http://dx.doi.org/10.1016/j.placenta.2008.10.012.