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Detail

Verena Pichler
Mag. Dr. Verena PichlerHead of Medical Radiochemistry and Biomarker Development; Head of Production PET-radiotracer

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)

ORCID: 0000-0003-4544-2438
T +43 1 40400 78300
verena.pichler@meduniwien.ac.at

Further Information

Keywords

Diagnostic Imaging; Drug Discovery; Positron-Emission Tomography; Radiochemistry

Research interests

Drug development of imaging and therapeutic probes radiolabelled with carbon-11, fluorine-18, gallium-68, lutetium-177 and their preclinical and clinical evaluation.

Techniques, methods & infrastructure

  • Drug development: synthetic inorganic and organic chemistry (schlenk technique), radiochemistry
  • Analytical drug investigations: analytical and preparative HPLC (stability, lipophilicity, metabolism), 2D- and 3D- NMR, UV-Vis and IR spectroscopy
  • In vitro techniques: preclinical 2D and 3D techniques (spheroid culture), antiproliferation assays, drug accumulation, FACS analysis, western blot, fluorescence microscopy

Selected publications

  1. Pichler, V. et al., 2015. Influence of reducing agents on the cytotoxic activity of platinum( iv ) complexes: induction of G 2 /M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines . Metallomics, 7(7), pp.1078-1090. Available at: http://dx.doi.org/10.1039/c5mt00116a.
  2. Pichler, V. et al., 2018. An Overview of PET Radiochemistry, Part 1: The Covalent Labels18F,11C, and13N. Journal of Nuclear Medicine, 59(9), pp.1350–1354. Available at: http://dx.doi.org/10.2967/jnumed.117.190793.
  3. Pichler, V. et al., 2013. Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery. Chemical Communications, 49(22), p.2249. Available at: http://dx.doi.org/10.1039/c3cc39258a.
  4. Pichler, V. et al., 2012. Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity. Journal of Medicinal Chemistry, 55(24), pp.11052-11061. Available at: http://dx.doi.org/10.1021/jm301645g.
  5. Pichler, V. et al., 2018. Molar activity – The keystone in 11C-radiochemistry: An explorative study using the gas phase method. Nuclear Medicine and Biology, 67, pp.21–26. Available at: http://dx.doi.org/10.1016/j.nucmedbio.2018.09.003.
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