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Detail

Karlheinz Hilber
Assoc. Prof. Dr. Karlheinz Hilber

Center for Physiology and Pharmacology (Division of Neurophysiology and Neuropharmacology)
Position: Associate Professor

T +43 1 40160 31230
karlheinz.hilber@meduniwien.ac.at

Keywords

Arrhythmias, Cardiac; Calcium Channels, L-Type; Cardiac Electrophysiology; Cardiomyopathy, Dilated; Muscular Dystrophy, Duchenne; Voltage-Gated Sodium Channels

Research group(s)

  • Cardiac electrophysiology and pharmacology

Research interests

  • Cardiac ion channel impairments in the diseased heart
  • Effects of drugs on cardiac ion channels

Techniques, methods & infrastructure

whole cell patch clamp technique, isolation of cardiomyocytes from neonatal and adult mouse and guinea pig hearts, muscular dystrophy mouse models, standard biochemistry and molecular biology 

Members of this research group have access to a cell culture, a standard biochemistry and molecular biology lab, and a patch clamp rig.

Grants

  • Voltage-gated ion channel dysfunction in dystrophic muscle (2010)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Cardiogenic substances (2009)
    Source of Funding: aws (Austria Wirtschaftsservice), PRIZE
    Principal Investigator
  • Ion channel plasticity in transforming skeletal muscle (2006)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Na channels in fast and slow skeletal muscle (2001)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator

Selected publications

  1. Rubi, L. et al., 2015. Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes. Cell Physiol Biochem, 36(3), pp.1049-1058. Available at: http://dx.doi.org/10.1159/000430278.
  2. Koenig, X. & Hilber, K., 2015. The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation. Molecules, 20(2), pp.2208-2228. Available at: http://dx.doi.org/10.3390/molecules20022208.
  3. Koenig, X. et al., 2013. Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart. AJP: Heart and Circulatory Physiology, 306(4), pp.H564-H573. Available at: http://dx.doi.org/10.1152/ajpheart.00441.2013.
  4. Koenig, X. et al., 2012. Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk. Addiction Biology, 19(2), pp.237-239. Available at: http://dx.doi.org/10.1111/j.1369-1600.2012.00447.x.
  5. Koenig, X. et al., 2011. Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart M. Rota, ed. PLoS ONE, 6(5), p.e20300. Available at: http://dx.doi.org/10.1371/journal.pone.0020300.