Bacterial Infections; Immunity, Innate; Inflammation; Macrophages
- Infection Biology Research Lab
We focus on a better understanding of the modulation of innate immune responses during clinically relevant bacterial infections and inflammatory diseases. The main focus is placed on the biological function and plasticity of macrophages in tissues infected by pathogens or injured in the course of inflammation. The long term objective pertains to an improved assessment of the regulation of inflammatory processes in order to identify novel therapeutic and diagnostic targets.
Techniques, methods & infrastructure
- Warszawska, J.M. et al., 2013. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J. Clin. Invest., 123(8), pp.3363-3372. Available at: http://dx.doi.org/10.1172/JCI67911.
- Matt, U. et al., 2013. WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J. Clin. Invest., 123(7), pp.3014-3024. Available at: http://dx.doi.org/10.1172/JCI60681.
- Sharif, O. et al., 2014. The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia C. J. Orihuela, ed. PLoS Pathogens, 10(6), p.e1004167. Available at: http://dx.doi.org/10.1371/journal.ppat.1004167.
- Gawish, R. et al., 2014. Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis. The FASEB Journal, 29(4), pp.1247-1257. Available at: http://dx.doi.org/10.1096/fj.14-260067.
- Sharif, O. et al., 2013. The Scavenger Receptor CD36 Downmodulates the Early Inflammatory Response while Enhancing Bacterial Phagocytosis during Pneumococcal Pneumonia. The Journal of Immunology, 190(11), pp.5640-5648. Available at: http://dx.doi.org/10.4049/jimmunol.1202270.