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Detail

Sylvia Knapp
Prof. Dr. Sylvia Knapp, PhDHead of Infection Biology Lab; Director of Medical Affairs at CeMM

Department of Medicine I
Position: Professor

ORCID: 0000-0001-9016-5244
T +43 1 40400 51390, 40160 70049
sylvia.knapp@meduniwien.ac.at

Further Information

Keywords

Bacterial Infections; Immunity, Innate; Inflammation; Macrophages

Research group(s)

  • Infection Biology Research Lab

Research interests

We focus on a better understanding of the modulation of innate immune responses during clinically relevant bacterial infections and inflammatory diseases. The main focus is placed on the biological function and plasticity of macrophages in tissues infected by pathogens or injured in the course of inflammation. The long term objective pertains to an improved assessment of the regulation of inflammatory processes in order to identify novel therapeutic and diagnostic targets. 

Techniques, methods & infrastructure

      

Grants

  • Chromatin Landscapes (2017)
    Source of Funding: FWF (Austrian Science Fund), Special Research Programmes (SFB)
    Principal Investigator
  • Haploid genetics, genome editing and pneumococcal recognition (2014)
    Source of Funding: FWF (Austrian Science Fund), ERA-Net; Infect-ERA
    Coordinator of the collaborative project
  • Immunothrombosis (2014)
    Source of Funding: FWF (Austrian Science Fund), Special Research Programmes (SFB)
    Principal Investigator
  • Cell Communication in Health and Disease (2010)
    Source of Funding: FWF (Austrian Science Fund), Doctoral Programs (DK)
    Principal Investigator

Selected publications

  1. Saluzzo, S. et al., 2017. First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. Cell Reports, 18(8), pp.1893-1905. Available at: http://dx.doi.org/10.1016/j.celrep.2017.01.071.
  2. Martins, R. et al., 2016. Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nature Immunology, 17(12), pp.1361-1372. Available at: http://dx.doi.org/10.1038/ni.3590.
  3. Sharif, O. et al., 2014. The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia C. J. Orihuela, ed. PLoS Pathogens, 10(6), p.e1004167. Available at: http://dx.doi.org/10.1371/journal.ppat.1004167.
  4. Matt, U. et al., 2013. WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. Journal of Clinical Investigation, 123(7), pp.3014-3024. Available at: http://dx.doi.org/10.1172/JCI60681.
  5. Warszawska, J.M. et al., 2013. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. Journal of Clinical Investigation, 123(8), pp.3363-3372. Available at: http://dx.doi.org/10.1172/JCI67911.