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Detail

Christoph Aufricht
Univ.-Prof. Dr.med.univ. Christoph AufrichtHead, Division of Pediatric Nephrology and Gastroenterology

Department of Pediatrics and Adolescent Medicine (Division of Pediatric Nephrology and Gastroenterology)
Position: Professor

T +43 1 40400 31880
christoph.aufricht@meduniwien.ac.at

Further Information

Keywords

Cytoprotection; Heat-Shock Response; Peritoneal Dialysis; Translational Medical Research; Ultrafiltration

Research interests

My laboratory focuses on cytotoxic damage in the model of peritoneal dialysis (PD). We describe and manipulate the cellular stress response in different in-vitro and in-vivo models of experimental PD, allowing improved cellular survival. Using systems-biology approaches we showed that stress responses in PD were not adequate for sufficient cytoprotection. In cooperation with the MedUni Vienna spin-off Zytoprotec, novel therapeutic interventions are developed in order to re-establish adequate cellular repair mechanism. Parallel to basic research we perform clinical research on the optimization of therapy for pediatric kidney transplantations and dialysis.  Translational and clinical-epidemiological studies led to the establishment of an interdisciplinary working group that brought improvements in the quality of our daily clinical care. All junior researchers are participating in the N790 PhD program POeT (Program for Organfailure-, replacement and Transplantation, link: http://www.meduniwien.ac.at/poet/en/poet/description.php).

Techniques, methods & infrastructure

Different models of experimental PD: biochemical analysis including FACS, Western blot, Immunofluorescence, proteomics, transcriptomics, metabolomics and clinical-epidemiological tools in cooperation with international registries (ERA-EDTA).

Selected publications

  1. Kratochwill K., Boehm M., Herzog R., Gruber K., Lichtenauer A.M., Kuster L., Csaicsich D., Gleiss A., Alper S.L., Aufricht C., Vychytil A. Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses - A First-In-Man Trial. PLoS One. 2016 Oct 21;11(10):e0165045. Pubmed-Link: https://www.ncbi.nlm.nih.gov/pubmed/27768727
  2. Bidmon-Fliegenschnee B., Lederhuber H., Csaicsich D., Pichler J., Herzog R., Memaran-Dadgar N., Huber W.D., Aufricht C., Kratochwill K. Overexpression of Hsp70 confers cytoprotection during gliadin exposure in Caco-2 cells. Pediatr Res. 2015 Oct;78(4):358-64. doi: 10.1038/pr.2015.112. Epub 2015 Jun 18. Pubmed-Link: http://www.ncbi.nlm.nih.gov/pubmed/ 26086640
  3. Herzog R., Bender T.O., Vychytil A., Bialas K., Aufricht C., Kratochwill K. Dynamic O-linked N-acetylglucosamine modification of proteins affects stress responses and survival of mesothelial cells exposed to peritoneal dialysis fluids. J Am Soc Nephrol. 2014 Dec;25(12):2778-88. Pubmed-Link: http://www.ncbi.nlm.nih.gov/pubmed/24854264
  4. Springer A, Kratochwill K, Bergmeister H, Csaicsich D, Huber J, Bilban M, Mayer B, Mühlberger I, Amann G, Horcher E, Aufricht C. A combined transcriptome and bioinformatics approach to unilateral ureteral obstructive uropathy in the fetal sheep model. J Urol. 2012 Feb;187(2):751-6. Pubmed-Link: http://www.ncbi.nlm.nih.gov/pubmed/22177204
  5. Boehm M. Winkelmayer WC. Arbeiter K., Mueller T., Aufricht C. Late referral to pediatric renal failure service impairs access to pre-emptive kidney transplantation in children. Arch Dis Child. 2010 Aug; 95(8):634-8. Pubmed-Link: http://www.ncbi.nlm.nih.gov/pubmed/20522470