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Detail

Verena Pichler
Mag. Dr. Verena Pichler

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)

T +43 1 40400 78300
verena.pichler@meduniwien.ac.at

Further Information

Keywords

Diagnostic Imaging; Drug Discovery; Positron-Emission Tomography; Radiochemistry

Research interests

My research interest are the development preclinical evaluation of radiopharmaceuticals. Currently, I focused on the establishment and development of hypoxia tracers and in vitro techniques for their investigations, based on spheroid cultures.

Techniques, methods & infrastructure

  • Drug development: synthetic inorganic and organic chemistry (schlenk technique), radiochemistry
  • Analytical drug investigations: analytical and preparative HPLC (stability, lipophilicity, metabolism), 2D- and 3D- NMR, UV-Vis and IR spectroscopy
  • In vitro techniques: preclinical 2D and 3D techniques (spheroid culture), antiproliferation assays, drug accumulation, FACS analysis, western blot, fluorescence microscopy

Selected publications

  1. Pichler, V. et al., 2015. Influence of reducing agents on the cytotoxic activity of platinum( iv ) complexes: induction of G 2 /M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines . Metallomics, 7(7), pp.1078-1090. Available at: http://dx.doi.org/10.1039/c5mt00116a.
  2. Pichler, V. et al., 2013. Bulky N (, N )-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes . Inorg. Chem., 52(14), pp.8151-8162. Available at: http://dx.doi.org/10.1021/ic400816g.
  3. Pichler, V. et al., 2013. Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery. Chemical Communications, 49(22), p.2249. Available at: http://dx.doi.org/10.1039/c3cc39258a.
  4. Pichler, V. et al., 2012. Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity. Journal of Medicinal Chemistry, 55(24), pp.11052-11061. Available at: http://dx.doi.org/10.1021/jm301645g.
  5. Pichler, V. et al., 2011. Mono-carboxylated diaminedichloridoplatinum(iv) complexes - selective synthesis, characterization, and cytotoxicity. Dalton Transactions, 40(32), p.8187. Available at: http://dx.doi.org/10.1039/c1dt10301f.