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Detail

Melanie Hassler
Mag. Melanie Hassler, Ph.D.

Department of Urology
Position: Research Associate (Postdoc)

T +43 1 40400 26120
melanie.hassler@meduniwien.ac.at

Keywords

Cell Culture Techniques; DNA Methylation; Epigenomics; Genomics; Translational Medical Research; Urinary Bladder Diseases

Research interests

My research focuses on epigenetics and the molecular pathology of bladder cancer. In the lab, we are using genome-scale analyses to detect sites of differential DNA methylation in primary human bladder tumors in order to define epigenetic biomarkers and to discover epigenetic drivers of tumorigenesis. By working in close contact with clinicians, we are exellently connected to current developments in uro-oncological diseases and focus on translating molecular findings to the clinics.

Techniques, methods & infrastructure

  • DNA methylation analysis 
  • Cell culture techniques
  • Immunohistochemistry and Imaging
  • Genetics&Molecular Biology (qRT-PCR, Western Blot, Sequencing, Cloning, ELISA, ChIP)

Selected publications

  1. Hassler, M.R. et al., 2016. Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling. Cell Reports, 17(2), pp.596-608. Available at: http://dx.doi.org/10.1016/j.celrep.2016.09.018.
  2. Xylinas, E. et al., 2016. An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer. Biomolecules, 6(3), p.37. Available at: http://dx.doi.org/10.3390/biom6030037.
  3. Pencik, J. et al., 2015. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nature Communications, 6, p.7736. Available at: http://dx.doi.org/10.1038/ncomms8736.
  4. Laimer, D. et al., 2012. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nature Medicine, 18(11), pp.1699-1704. Available at: http://dx.doi.org/10.1038/nm.2966.
  5. Hassler, M.R. & Egger, G., 2012. Epigenomics of cancer - emerging new concepts. Biochimie, 94(11), pp.2219-2230. Available at: http://dx.doi.org/10.1016/j.biochi.2012.05.007.