Apolipoprotein B-100; Blood Pressure; Endocytosis; Epithelial Cells; Immunohistochemistry; Iron; Methylmercury Compounds; Microscopy; Placenta; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, IgG; Transcytosis
- Pathophysiology of the placenta
My main research interests are to study uptake, traffic and effects of maternal (macro-)molecules such as IgG, MeHg, iron or Apolipoproteins at the materno-fetal interface (placenta) and the advancement of automated microscopy. For the past 11 years (after return from a five year maternity leave) I have been involved in several national and European research projects as well as teaching/research cooperations with the Comenius University in Bratislava/Slovakia. An important achievement has been the development of algorithms for automated detection of cells in tissue sections or cell culture systems within an interdisciplinary, FFG-funded cooperation with TissueGnostics GmbH (2009-2013).
Techniques, methods & infrastructure
My research group is part of the Division of Cellular and Molecular Pathophysiology iat IPA. Our devision is dedicated to basic and disease-oriented research covering various stages of the human life span. Living organisms are complex systems and diseases manifest themselves as a consequence of impaired functions at the molecular, cellular, and organ level. Our research aims at investigating diseases by means of various model systems (in situ, in vitro, ex vivo) that reflect this complexity to obtain an integrated view of the disease. The final goal of our research is the improvement of diagnosis, treatment and prevention of diseases.
The division combines specialists in distinct morphological techniques. We provide the expertise for and help with the experimental design in immunohistochemistry and immunofluorescence microscopy, quantitative image analysis, life cell imaging, confocal fluorescence microscopy, and bone morphometry (including histomorphometry and micro-computed tomography).
- Kamper, M. et al., 2017. Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast-derived BeWo cells. Biochimie, 138, pp.116-123. Available at: http://dx.doi.org/10.1016/j.biochi.2017.05.006.
- Ellinger, I., 2016. The Calcium-Sensing Receptor and the Reproductive System. Frontiers in Physiology, 7. Available at: http://dx.doi.org/10.3389/fphys.2016.00371.
- Ellinger, I. et al., 2016. Don�t trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface. Placenta, 43, pp.13-16. Available at: http://dx.doi.org/10.1016/j.placenta.2016.04.011.
- Straka, E. et al., 2016. Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters. Toxicology, 340, pp.34-42. Available at: http://dx.doi.org/10.1016/j.tox.2015.12.005.
- Madritsch, C. et al., 2015. Antibody conjugates bispecific for intercellular adhesion molecule 1 and allergen prevent migration of allergens through respiratory epithelial cell layers. Journal of Allergy and Clinical Immunology, 136(2), pp.490-493.e11. Available at: http://dx.doi.org/10.1016/j.jaci.2015.01.006.