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Detail

Robert Eferl
Robert EferlPrinciple Investigator

Department of Medicine I (Institute of Cancer Research)
Position: Associate Professor

T +43 1 40160 57571
robert.eferl@meduniwien.ac.at

Further Information

Research group(s)

  • Robert Eferl

Research interests

  • Basic biomedical science to identify functions of transcription factors in diseases
  • Development of transgenic mouse models for cooperative mutations in cancer development
  • Investigation of molecular and cellular processes in the tumor microenvironment that influence cancer formation with a focus on tumor-associated macrophages and STAT3
  • Cytokine signaling in cholestatic liver fibrosis, hepatocellular carcinomas and formation of colorectal tumors with a focus on transcription factors STAT1 and STAT3

Techniques, methods & infrastructure

  • Generation of transgenic, knockout and knockin mice
  • Mouse models with conditional deletion of STAT1, STAT3 or CDHR5 in intestinal epithelial cells, hepatocytes, macrophages and fibroblasts
  • Mouse tumor models for colorectal cancer, intestinal cancer and liver cancer (hepatocellular carcinoma)
  • Preparation of swiss roles and mouse tumor analysis
  • Quantitative histomorphometry of IHC (immunohistochemical) stainings and immunofluorescence with Definiens software
  • Quantitation of tumor vessel parameters (wall thickness, lumen, vessel numbers, vessel size)
  • Characterization of immune cell infiltrates in tumors using immunohistochemistry and FACS

Selected publications

  1. Pathria, P. et al., 2015. Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice . OncoImmunology, 4(4), p.e998529. Available at: http://dx.doi.org/10.1080/2162402X.2014.998529.
  2. Crncec, I. et al., 2015. Induction of Colorectal Cancer in Mice and Histomorphometric Evaluation of Tumors. Mouse Models of Cancer, pp.145-164. Available at: http://dx.doi.org/10.1007/978-1-4939-2297-0_7.
  3. Musteanu, M. et al., 2012. A mouse model to identify cooperating signaling pathways in cancer. Nat Meth, 9(9), pp.897-900. Available at: http://dx.doi.org/10.1038/nmeth.2130.
  4. Mair, M. et al., 2010. Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis. Gastroenterology, 138(7), pp.2499-2508. Available at: http://dx.doi.org/10.1053/j.gastro.2010.02.049.
  5. Musteanu, M. et al., 2010. Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice. Gastroenterology, 138(3), pp.1003-1011.e5. Available at: http://dx.doi.org/10.1053/j.gastro.2009.11.049.