Detail

Keywords

Cochlea; Cochlear Implantation; Drug Delivery Systems; Evoked Potentials; Hearing Loss; Neurotology; Translational Medical Research

Research group(s)

• Christian Doppler Lab for Inner Ear Research
  Head: Christoph Arnoldner
  Research Area: This CD laboratory investigates the underlying mechanisms of inner ear diseases and researches various therapeutic approaches for the treatment of hearing loss. The high prevalence of hearing loss worldwide and the expected increase in hearing loss require innovative research strategies to improve patient care.
  Members:
  Christoph Arnoldner
  Anselm J. Gadenstaetter
  Matthias Gerlitz
  Erdem Yildiz

Research interests

Erdem Yildiz is an Otorhinolaryngology resident at Vienna General Hospital and a researcher at the Vienna Inner Ear Lab (Medical University of Vienna). He received his medical degree in 2020 and focuses on inner-ear pathophysiology and translational strategies for local drug and gene delivery. During his PhD, he gained extensive hands-on experience with large-animal models and microsurgical techniques enabling targeted delivery to the middle and inner ear.

In parallel, he contributes to clinical research in cochlear implantation and neuro-otology, including prospective outcome studies on vestibular schwannoma and intraoperative neuromonitoring, as well as long-term follow-up of various temporal bone tumors. He is also involved in translational biomarker work (e.g., prestin in human perilymph, cerebrospinal fluid, and blood) and imaging-based projects supporting surgical planning in cochlear implant candidates.

Selected publications

1. Yildiz, E. et al. (2022) ‘Single-incision cochlear implantation and hearing evaluation in piglets and minipigs’, Hearing Research, 426, p. 108644. Available at: https://doi.org/10.1016/j.heares.2022.108644.
2. Yildiz, E. et al. (2023) ‘Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics’, Frontiers in Pharmacology, 14. Available at: https://doi.org/10.3389/fphar.2023.1062379.
3. Buswinka, C.J. et al. (2024) ‘Large-scale annotated dataset for cochlear hair cell detection and classification’, Scientific Data, 11(1). Available at: https://doi.org/10.1038/s41597-024-03218-y.
4. Yildiz, E. et al. (2021) ‘Long-Term Outcome and Comparison of Treatment Modalities of Temporal Bone Paragangliomas’, Cancers, 13(20), p. 5083. Available at: https://doi.org/10.3390/cancers13205083.
5. Gadenstaetter, A.J. et al. (2023) ‘Functional Outcome After Simultaneous Vestibular Schwannoma Resection and Cochlear Implantation With Intraoperative Cochlear Nerve Monitoring’, Otolaryngology–Head and Neck Surgery, 168(6), pp. 1502–1510. Available at: https://doi.org/10.1002/ohn.233.