Optical Imaging; Physics; Tomography, Optical Coherence
Optical methods enable rapid, noninvasive, and three-dimensional imaging with micrometer scale resolution. My research interests are the development of new optical methods for biomedical imaging – in particular optical coherence tomography (OCT) – and their application for improved diagnostics of diseases in both clinical and preclinical research.
Techniques, methods & infrastructure
- Optical imaging setups for retinal and microscopic imaging
- Image processing and analysis
- Longitudinal studies in biomedical research settings
- OPTIMALZ - Optical imaging of ocular pathology in Alzheimer’s disease (2015)
Source of Funding: EU, ERC-2014-STG
- Preclinical imaging of the rodent eye with multi-functional optical coherence tomography (2013)
Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
- Harper, D.J. et al., 2020. Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography. Neurophotonics, 7(01), p.1. Available at: http://dx.doi.org/10.1117/1.NPh.7.1.015006.
- Merkle, C. et al., 2020. Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo. Optics Letters. Available at: http://dx.doi.org/10.1364/OL.380051.
- Baumann, B. et al., 2019. Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when? Biomedical Optics Express, 10(11), p.5755. Available at: http://dx.doi.org/10.1364/BOE.10.005755.
- Eugui, P. et al., 2019. Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography. Optics Letters, 44(16), p.4040. Available at: http://dx.doi.org/10.1364/OL.44.004040.
- Lichtenegger, A. et al., 2019. Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging. Journal of Biomedical Optics, 24(06), p.1. Available at: http://dx.doi.org/10.1117/1.JBO.24.6.066010.